The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.
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【Association between the intake of α-linolenic acid and the risk of CHD.].
【Α-亚麻酸摄入量与冠心病风险之间的关联。】
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DOI：10.1017/S000711451400138X文章类型：杂志文章
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据报道，主要由植物来源的n-3 PUFA α-亚麻酸 (ALA) 的摄入与较低的冠心病风险有关。然而，结果并不一致。因此，本研究的目的是检查摄入ALA与冠心病风险之间的关联。还研究了长链n-3 PUFA (n-3 LCPUFA) 摄入的潜在效应修饰。使用了来自八项美国和欧洲前瞻性队列研究的数据，其中包括148名675女性和80名368男性。结果指标为冠心病事件 (冠心病事件和死亡)。在4-10年的随访期间，发生了4493例CHD事件和1751例CHD死亡。在男性中，观察到ALA的摄入量与CHD事件和死亡的风险之间呈负相关 (不显着)。每消耗一克ALA，冠心病事件的风险就会15% 降低 (危险比 (HR) 0·85，95% CI 0·72,1·01)，冠心病死亡的风险也会23% 降低 (HR 0·77，95% CI 0·58，观察到1·01)。在女性中没有观察到一致的关联。未观察到摄入n-3 LCPUFA的影响。
