Sixteen patients with advanced cervix cancer have been treated in a phase I/II study of concurrent radiotherapy and cisplatin chemotherapy. The external beam radiotherapy was given as a 'split course' because of initial concerns about acute toxicity. The treatment was well tolerated with all patients completing the prescribed radiotherapy and all patients received the intended four doses of cisplatin. One of 5 patients with stage IVB disease is alive and disease free 35 months after treatment. Six of the 11 patients with disease confined to the pelvis are alive and disease free between 28 and 53 months after treatment. One patient has required surgery for a recto-sigmoid stricture.

译文

在同步放疗和顺铂化疗的I/II期研究中,已对16例晚期宫颈癌患者进行了治疗。由于最初对急性毒性的担忧,将外部束放射治疗作为 “分裂过程”。所有患者均完成了规定的放射治疗,并且所有患者均接受了预期的四剂顺铂,治疗耐受性良好。5例IVB期患者中有1例在治疗后35个月存活且无病。11名局限于骨盆的患者中有6名在治疗后28至53个月内存活且无疾病。一名患者因直肠乙状结肠狭窄需要手术治疗。

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