The aim of this study was to assess the clinical value of serum oestradiol concentration 8 days after embryo transfer (D8E2) and beta-human chorionic gonadotrophin (HCG-beta) concentration 12 days after embryo transfer (D12HCG-beta) in the prediction of pregnancy and the outcome of pregnancy following assisted reproduction, taking into account the day of transfer, which was either day 3 (D3) or day 5 (D5). The objective was to improve patient counselling by giving quantitative and reliable predictive information instead of non-specific uncertainties. A total of 2035 embryo transfer cycles performed between January 2003 and June 2005 were analysed retrospectively. Biochemical pregnancy, ectopic pregnancy and first-trimester abortions were classified as non-viable pregnancies; pregnancies beyond 12 weeks gestation were classified as ongoing pregnancies (OP). Significantly higher D8E2 and D12HCG-beta were obtained in D5 transfers compared with D3 transfers with regard to pregnancy and OP (P
译文
：这项研究的目的是评估胚胎移植后8天（D8E2）和β-人绒毛膜促性腺激素（HCG-beta）浓度在胚胎移植12天后（D12HCG-beta）的临床价值，以预测糖尿病的发生。怀孕和辅助生殖后的怀孕结局，要考虑到转移的那天，即第3天（D3）或第5天（D5）。目的是通过提供定量和可靠的预测信息而不是非特定的不确定性来改善患者咨询。回顾性分析了2003年1月至2005年6月进行的2035个胚胎移植周期。生化妊娠，异位妊娠和早孕流产被归类为不可行的妊娠。妊娠超过12周的孕妇被分类为进行中的孕妇（OP）。与妊娠和OP的D3转移相比，D5转移获得的D8E2和D12HCG-beta明显更高（P <或= 0.001）。对于D3胚胎移植，D8E2预测OP的临界值为130 pg / ml（敏感性80％，特异性72％），而D12HCG-beta为98 mIU / ml（敏感性89％，特异性69％）。对于D5胚胎移植，该值分别为179 pg / ml（敏感性为79％，特异性为84％）和257 mIU / ml（敏感性为78％，特异性为81％）。看来，胚胎移植后血清D8E2和D12HCG-β的浓度提供了有关妊娠以及IVF胚胎移植后妊娠结局的明确信息。
