Growth hormone deficiency (GHD) related to standard dose chemotherapy has rarely been described. We report on a case of localized ganglioneuroblastoma treated by carboplatin/etoposide for 2 courses and surgery, which developed a serious GHD after 56 months. At present, the child is growing on by GH replacement therapy. We discuss about the hypothesis that GHD may be related to chemotherapy and we report a review of previous published cases.

译文

:很少有人描述与标准剂量化疗有关的生长激素缺乏症(GHD)。我们报告了一例通过卡铂/依托泊苷治疗的局部神经节神经母细胞瘤的疗程为2个疗程和手术,该病例在56个月后出现了严重的GHD。目前,孩子正在通过GH替代疗法长大。我们讨论了GHD可能与化学疗法有关的假说,并且我们报告了以前发表过的病例的综述。

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