The myocardial protective effect of captopril cardioplegia was investigated through the recovery of cardiac functions, biochemical changes and ultrastructural assays in the isolated working rabbit heart after hypothermic ischemic arrest for 3 hours. Hearts were randomly divided into 3 groups with 8 in each. Another 3 groups of hearts (8 in each) were arranged for studying the biochemical changes and ultrastructure during the ischemic period. In the control group (I), the hearts were protected by the modified St. Thomas' cardioplegic solution No. I, while in Group II and III the cardioplegic solutions contained 2.3 mumol/L and 23 mumol/L captopril respectively. The results showed that the percent recoveries of cardiac function in the 23 mumol/L captopril group compared with the control group were 97.9 +/- 9.8% vs 84.9 +/- 7.3% in left ventricular peak systolic pressure (P less than 0.01), 118 +/- 33% vs 79 +/- 20% in +dp/dt max (P less than 0.01), 111 +/- 22% vs 75 +/- 18% in -dp/dt max (P less than 0.01), 145.6 +/- 44.8% vs 76.7 +/- 18% in coronary flow (P less than 0.01), 120.2 +/- 45.7% vs 36.4 +/- 22.2% in aortic flow (P less than 0.01), 127.4 +/- 27.3% vs 56.1 +/- 14% in cardiac output (P less than 0.01), and 118.2 +/- 33.5% vs 52.5 +/- 19.9% in stroke volume (P less than 0.01) respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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【Myocardial protective effect of captopril cardioplegia on ischemia and reperfusion injury in the isolated rabbit heart.].
【卡托普利心脏停搏对离体兔心脏缺血和再灌注损伤的心肌保护作用。】
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卡托普利心脏停搏的心肌保护作用是通过低温缺血性停搏3小时后分离的工作兔心脏的心脏功能恢复，生化变化和超微结构分析来研究的。将心脏随机分为3组，每组8个。安排另外3组心脏（每组8个）用于研究缺血期的生化变化和超微结构。在对照组（I）中，心脏受到改良的I型圣托马斯心脏停搏液的保护，而在第二组和第三组中，心脏停搏液分别含有2.3摩尔/升和23摩尔/升的卡托普利。结果显示，卡托普利组23摩尔/升与对照组相比，心功能恢复百分率分别为97.9 /-9.8％和84.9 /-7.3％（P小于0.01），118 / -dp / dt max的33％vs 79 /-20％（P小于0.01），111 /-22％vs-dp / dt max的75％-18％（P小于0.01），145.6 /-44.8％ vs冠脉血流76.7 /-18％（P小于0.01），主动脉血流120.2 /-45.7％vs 36.4 /-22.2％（心脏小于P）0.01、127.4 /-27.3％vs 56.1 /-14％输出（P小于0.01）和118.2 /-33.5％对52.5 /-19.9％的笔触量（P小于0.01）（摘要截断为250个字）
