OBJECTIVE:The objective was to investigate the clinical features and metabolic and anatomic risk factors for kidney stone formation in our patient group. METHODS:Between 1998 and 2005, 179 children (94 girls, 85 boys) followed in our department because of urolithiasis were enrolled to participate in our study. Clinical presentation, urinary tract infection, stone localisation, positive family history, stone composition, presence of anatomic abnormalities and urinary metabolic risk factors, and treatment modality were evaluated retrospectively. RESULTS:The mean age at diagnosis of stone disease was 4.5 years (range 0.25-15.3 years). The mean follow-up duration was 8 months (range 1-98). The major clinical presentations of our patients were abdominal pain and/or flank pain in 100 children (55.9%) and macroscopic hematuria in 25 (14%). Urinary tract infection was detected in 20% of patients on admission. Forty-three children (24%) had a urinary tract abnormality and ureteropelvic junction obstruction was the most common abnormality. A family history of stone disease was recorded in 98 patients (54.7%). Stones were located within the renal parenchyma in 90 patients. Hypercalciuria and hyperuricosuria were detected in 42.3 and 54.8% respectively. Stone analysis was performed in 63 children and calcium oxalate was a major mineral. Surgical treatment was performed in 49 children and extracorporeal shock wave lithotripsy (ESWL) in 41 children. CONCLUSION:We think that urolithiasis remains a serious problem in children in our country. Family history of urolithiasis, urologic abnormalities (especially under the age of 5 years), metabolic disorders and urinary tract infections tend to indicate childhood urolithiasis.

译文

目的:探讨本组患者肾结石形成的临床特征以及代谢和解剖危险因素。
方法:在1998年至2005年之间,由于尿路结石而在我科随访的179名儿童(94名女孩,85名男孩)参加了我们的研究。回顾性评估临床表现,尿路感染,结石定位,阳性家族史,结石成分,解剖学异常和尿代谢危险因素的存在以及治疗方式。
结果:诊断为结石病的平均年龄为4.5岁(范围为0.25-15.3岁)。平均随访时间为8个月(范围1-98)。我们患者的主要临床表现为100名儿童(55.9%)的腹痛和/或胁腹痛和25名儿童(14%)的肉眼血尿。入院时有20%的患者检测到尿路感染。 43名儿童(占24%)患有尿路异常,输尿管盆腔交界处梗阻是最常见的异常。记录了98例(54.7%)的家族结石病史。结石位于肾实质内的90例患者中。尿钙尿过多和尿尿尿过多的检出率分别为42.3和54.8%。对63名儿童进行了结石分析,草酸钙是主要矿物质。对49例儿童进行了手术治疗,对41例儿童进行了体外冲击波碎石术(ESWL)。
结论:我们认为尿石症在我国儿童中仍然是一个严重的问题。尿石症的家族病史,泌尿系统异常(尤其是5岁以下),代谢异常和尿路感染往往表明儿童期尿石症。

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