Eight patients with chronic obstructive lung disease (COLD) and pulmonary hypertension were given an infusion of a calcium antagonist, felodipine, during ongoing, long-term oxygen treatment (LTOT). The effects on central haemodynamics and ventilation-perfusion matching were studied. At rest pulmonary and systemic vascular resistances (PVR and SVR) were reduced by 18% (NS) and 26% (p less than 0.05), respectively. Cardiac output increased by 23%. There was a tendency to increased perfusion of low alveolar ventilation-perfusion ratio (VA/Q) areas (VA/Q less than 0.1) and to increased shunt compared to pretreatment values. Arterial oxygen tension (PaO2) fell by 0.7 kPa (p less than 0.001) but total oxygen transport increased by 23% (p less than 0.001). After treatment with oral felodipine (7.5-15 mg.day-1) for a mean time of 14 wks, PVR and SVR were reduced by 16% (p less than 0.05) and 7% (NS), respectively, as compared to pretreatment values at rest. Cardiac output rose by 13%. The VA/Q ratios and the PaO2 returned towards pretreatment values. The total oxygen transport increased by 11% (p less than 0.05) at rest and increased by 19% (p less than 0.05) during exercise as compared to the pretreatment value. The positive effect on central haemodynamics indicates that felodipine may be a valuable adjunct to ongoing LTOT.
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【The use of a vasodilator, felodipine, as an adjuvant to long-term oxygen treatment in COLD patients.].
【在COLD患者中使用血管扩张剂非洛地平作为长期氧气治疗的佐剂。】
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DOI：文章类型：杂志文章
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：在进行中的长期氧气治疗（LTOT）期间，向8位患有慢性阻塞性肺疾病（COLD）和肺动脉高压的患者输注了钙拮抗剂非洛地平。研究了对中央血流动力学和通气-灌注匹配的影响。静止时，肺和全身血管阻力（PVR和SVR）分别降低了18％（NS）和26％（p小于0.05）。心输出量增加了23％。与预处理值相比，低肺泡通气-灌注比（VA / Q）区域的灌注增加（VA / Q小于0.1），分流增加。动脉血氧张力（PaO2）下降了0.7 kPa（p小于0.001），但总氧输送增加了23％（p小于0.001）。与预处理相比，口服非洛地平（7.5-15 mg.day-1）平均治疗14周后，PVR和SVR分别降低了16％（p小于0.05）和7％（NS）。静止值。心输出量增长了13％。 VA / Q比和PaO2返回到预处理值。与治疗前的值相比，静止时的总氧气输送量增加了11％（p小于0.05），而在运动过程中的总氧气输送量增加了19％（p小于0.05）。对中枢血流动力学的积极影响表明，非洛地平可能是正在进行的LTOT的有价值的辅助药物。
