• 【量化睡眠周期性肢体运动的腿部活动: 系统评价和荟萃分析。】 复制标题 收藏 收藏
    DOI:10.1016/j.smrv.2014.02.004 复制DOI
    作者列表:Plante DT
    BACKGROUND & AIMS: :Periodic limb movements of sleep (PLMS) are repetitive, stereotyped movements that can disrupt sleep and result in insomnia, non-restorative sleep, and/or daytime sleepiness. Currently, polysomnography is the gold standard and only clinically acceptable means of quantifying PLMS. Leg-worn actigraphy is an alternative method of measuring PLMS, which may circumvent many of the economic and technical limitations of polysomnography to quantify nocturnal leg movements. However, the use of leg actigraphy as a diagnostic means of assessing PLMS has not been systematically evaluated. In this review, the use of leg-worn actigraphy to measure PLMS is systematically evaluated, using both qualitative and quantitative assessment. Findings demonstrate significant heterogeneity among a limited number of studies in terms of type of actigraph utilized, position of the device on the lower extremity, and methods employed to count PLMS. In general, common accelerometers vary in their sensitivity and specificity to detect PLMS, which is likely related to the technical specifications of a given device. A current limitation in the ability to combine data from actigraphs placed on both legs is also a significant barrier to their use in clinical settings. Further research is required to determine the optimal methods to quantify PLMS using leg actigraphy, as well as specific clinical situations in which these devices may prove most useful.
    背景与目标: : 周期性的肢体睡眠运动 (plm) 是重复的,刻板的运动,可能会破坏睡眠并导致失眠,非恢复性睡眠和/或白天嗜睡。目前,多导睡眠监测是定量plm的金标准,并且是临床上可接受的方法。腿部运动描记术是一种测量plm的替代方法,它可以规避多导睡眠描记术量化夜间腿部运动的许多经济和技术限制。但是,尚未系统地评估使用腿部活动描记术作为评估plm的诊断手段。在这篇综述中,使用定性和定量评估系统地评估了使用腿穿的动作描记术来测量plm。研究结果表明,在使用的活动仪类型,设备在下肢的位置以及用于计数plm的方法方面,在数量有限的研究中存在显着的异质性。通常,常见的加速度计检测plm的灵敏度和特异性各不相同,这可能与给定设备的技术规格有关。当前对来自两条腿上的活动图的数据进行组合的能力的限制也是其在临床环境中使用的重大障碍。需要进一步的研究来确定使用腿部活动仪量化plm的最佳方法,以及这些设备可能最有用的特定临床情况。
  • 【在人们的日常活动中,24小时动态记录脑血流动力学,全身血流动力学,心电图和运动描记术。】 复制标题 收藏 收藏
    DOI:10.1117/1.JBO.19.4.047003 复制DOI
    作者列表:Zhang Q,Ivkovic V,Hu G,Strangman GE
    BACKGROUND & AIMS: :The feasibility and utility of wearable 24-h multimodality neuromonitoring during daily activities are demonstrated. We have developed a fourth-generation ambulatory near infrared spectroscopy device, namely NINscan 4. NINscan 4 enables recording of brain function (via cerebral hemodynamics), systemic hemodynamics, electrocardiography, and actigraphy simultaneously and continuously for up to 24 h at 250-Hz sampling rate, during (and with minor restriction to) daily activities. We present initial 24-h human subject test results, with example analysis including (1) comparison of cerebral perfusion and oxygenation changes during wakefulness and sleep over a 24-h period and (2) capturing of hemodynamic changes prior, during and after sudden waken up in the night during sleep. These results demonstrate the first ambulatory 24-h cerebral and systemic hemodynamics monitoring, and its unique advantages including long-term data collection and analysis capability, ability to catch unpredictable transient events during activities of daily living, as well as coregistered multimodality analysis capabilities. These results also demonstrate that NINscan 4's motion artifact at 1-g head movement is smaller than physiological hemodynamic fluctuations during motionless sleep. The broader potential of this technology is also discussed.
    背景与目标: : 证明了日常活动中可穿戴24小时多模态神经监测的可行性和实用性。我们开发了第四代动态近红外光谱装置,即NINscan 4。NINscan 4能够在日常活动期间 (并对其进行少量限制) 以250Hz采样率同时记录脑功能 (通过脑血流动力学),全身血流动力学,心电图和动态描记术长达24小时。我们提供了最初的24小时人体受试者测试结果,并进行了实例分析,包括 (1) 在24小时内清醒和睡眠期间脑灌注和氧合变化的比较,以及 (2) 在睡眠中突然醒来之前,期间和之后捕获血液动力学变化。这些结果证明了首次动态24小时脑和全身血流动力学监测,其独特的优势包括长期数据收集和分析能力,在日常生活活动中捕捉不可预测的短暂事件的能力,以及共同注册的多模态分析能力。这些结果还表明,NINscan 4在1-g头部运动时的运动伪影小于静止睡眠期间的生理血液动力学波动。还讨论了该技术的更广泛潜力。
  • 【Actigraphy-测量睡眠中断作为晚期乳腺癌女性生存率的预测指标。】 复制标题 收藏 收藏
    DOI:10.5665/sleep.3642 复制DOI
    作者列表:Palesh O,Aldridge-Gerry A,Zeitzer JM,Koopman C,Neri E,Giese-Davis J,Jo B,Kraemer H,Nouriani B,Spiegel D
    BACKGROUND & AIMS: BACKGROUND:Poor sleep, prevalent among cancer survivors, is associated with disrupted hormonal circadian rhythms and poor quality of life. Using a prospective research design, this study aimed to clarify the relationship between objective measures of sleep efficiency and sleep disruption with survival among women with advanced breast cancer. METHOD:We examined sleep quality and duration via wrist-worn actigraphy and sleep diaries for 3 days among 97 women in whom advanced breast cancer was diagnosed (age = 54.6 ± 9.8 years). Sleep efficiency was operationalized using actigraphy as the ratio of total sleep time to total sleep time plus wake after sleep onset. RESULTS:As hypothesized, better sleep efficiency was found to predict a significant reduction in overall mortality (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.94-0.98; P < 0.001) at median 6 y follow-up. This relationship remained significant (HR, 0.94; 95% CI, 0.91-0.97; P < 0.001) even after adjusting for other known prognostic factors (age, estrogen receptor status, cancer treatment, metastatic spread, cortisol levels, and depression). Secondary hypotheses were also supported (after adjusting for baseline prognostic factors) showing that less wake after sleep onset (HR, 0.41; 95% CI, 0.25-0.67; P < 0.001), fewer wake episodes, (HR, 0.93; 95% CI, 0.88-0.98; P = 0.007); and shorter wake episode duration (HR, 0.29; 95% CI, 0.14-0.58; P < 0.001) also contributed to reductions in overall mortality. CONCLUSIONS:These findings show that better sleep efficiency and less sleep disruption are significant independent prognostic factors in women with advanced breast cancer. Further research is needed to determine whether treating sleep disruption with cognitive behavioral and/or pharmacologic therapy could improve survival in women with advanced breast cancer.
    背景与目标:
  • 【软件阈值会改变运动学用于监视团队运动运动员睡眠的偏差。】 复制标题 收藏 收藏
    DOI:10.1016/j.jsams.2016.11.021 复制DOI
    作者列表:Fuller KL,Juliff L,Gore CJ,Peiffer JJ,Halson SL
    BACKGROUND & AIMS: OBJECTIVES:Actical® actigraphy is commonly used to monitor athlete sleep. The proprietary software, called Actiware®, processes data with three different sleep-wake thresholds (Low, Medium or High), but there is no standardisation regarding their use. The purpose of this study was to examine validity and bias of the sleep-wake thresholds for processing Actical® sleep data in team sport athletes. DESIGN:Validation study comparing actigraph against accepted gold standard polysomnography (PSG). METHODS:Sixty seven nights of sleep were recorded simultaneously with polysomnography and Actical® devices. Individual night data was compared across five sleep measures for each sleep-wake threshold using Actiware® software. Accuracy of each sleep-wake threshold compared with PSG was evaluated from mean bias with 95% confidence limits, Pearson moment-product correlation and associated standard error of estimate. RESULTS:The Medium threshold generated the smallest mean bias compared with polysomnography for total sleep time (8.5min), sleep efficiency (1.8%) and wake after sleep onset (-4.1min); whereas the Low threshold had the smallest bias (7.5min) for wake bouts. Bias in sleep onset latency was the same across thresholds (-9.5min). The standard error of the estimate was similar across all thresholds; total sleep time ∼25min, sleep efficiency ∼4.5%, wake after sleep onset ∼21min, and wake bouts ∼8 counts. CONCLUSIONS:Sleep parameters measured by the Actical® device are greatly influenced by the sleep-wake threshold applied. In the present study the Medium threshold produced the smallest bias for most parameters compared with PSG. Given the magnitude of measurement variability, confidence limits should be employed when interpreting changes in sleep parameters.
    背景与目标:
  • 【精神分裂症的活动学研究以及临床和生物行为相关性: 系统评价。】 复制标题 收藏 收藏
    DOI:10.1007/s00702-019-01993-2 复制DOI
    作者列表:Wee ZY,Yong SWL,Chew QH,Guan C,Lee TS,Sim K
    BACKGROUND & AIMS: :Actigraphy is a non-invasive method of monitoring circadian rhythms and motor activity. We systematically reviewed extant evidence until September 2018 pertaining to actigraphy use in schizophrenia, its clinical/biological correlates and posit future research directions. Within 38 included studies involving 2700 subjects, patients with schizophrenia generally have lower motor activity levels, poorer sleep quality and efficiency, increased sleep fragmentation and duration compared with healthy controls. Lowered motor activity and longer sleep duration in patients were associated with greater severity of negative symptoms. Less structured motor activity and decreased sleep quality were associated with greater severity of positive symptoms, worse cognitive functioning involving attention and processing speed, illness chronicity, higher antipsychotic dose, and poorer quality of life. Correlations of actigraphic measures with biological factors are sparse with inconclusive results. Future studies with larger sample sets may adopt a multimodal, longitudinal approach which examines both motor and sleep activity, triangulates clinical, actigraphic and biological measures to clarify their inter-relationships and inform risk prediction of illness onset, course, and treatment response over time.
    背景与目标: : 活动描记法是一种监测昼夜节律和运动活动的非侵入性方法。我们系统地回顾了现存的证据,直到与精神分裂症中使用活动性技术有关的2018年9月,其临床/生物学相关性以及未来的研究方向。在38项涉及2700名受试者的研究中,与健康对照组相比,精神分裂症患者通常具有较低的运动活动水平,较差的睡眠质量和效率,增加的睡眠碎片和持续时间。患者的运动活动降低和睡眠时间延长与阴性症状的严重程度相关。较少的结构化运动活动和睡眠质量下降与阳性症状的严重程度,涉及注意力和处理速度的认知功能差,疾病的长期性,较高的抗精神病药剂量和较差的生活质量相关。活动性测量与生物因素的相关性很少,结果不确定。具有较大样本集的未来研究可能会采用多模式,纵向方法,该方法检查运动和睡眠活动,对临床,活动和生物学措施进行三角测量,以阐明它们之间的相互关系,并告知疾病发作,病程和治疗反应随时间推移的风险预测。
  • 【用于评估帕金森氏病睡眠措施的活动造影。】 复制标题 收藏 收藏
    DOI:10.5665/sleep.2888 复制DOI
    作者列表:Maglione JE,Liu L,Neikrug AB,Poon T,Natarajan L,Calderon J,Avanzino JA,Corey-Bloom J,Palmer BW,Loredo JS,Ancoli-Israel S
    BACKGROUND & AIMS: OBJECTIVES:To assess the usefulness of actigraphy for assessment of nighttime sleep measures in patients with Parkinson's disease (PD). DESIGN:Participants underwent overnight sleep assessment simultaneously by polysomnography (PSG) and actigraphy. SETTING:Overnight sleep study in academic sleep research laboratory. PARTICIPANTS:Sixty-one patients (mean age 67.74 ± 8.88 y) with mild to moderate PD. MEASUREMENTS:Sleep measures including total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), and sleep onset latency (SOL) were calculated independently from data derived from PSG and from actigraphy. Different actigraphy scoring settings were compared. RESULTS:No single tested actigraphy scoring setting was optimal for all sleep measures. A customized setting of an activity threshold of 10, with five consecutive immobile minutes for sleep onset, yielded the combination of mean TST, SE, and WASO values that best approximated mean values determined by PSG with differences of 6.05 ± 85.67 min for TST, 1.1 ± 0.641% for SE, and 4.35 ± 59.56 min for WASO. There were significant but moderate correlations between actigraphy and PSG measurements (rs = 0.496, P < 0.001 for TST, rs = 0.384, P = 0.002 for SE, and rs = 0.400, P = 0.001 for WASO) using these settings. Greater disease stage was associated with greater differences between TST (R(2) = 0.099, beta = 0.315, P = 0.018), SE (R(2) = 0.107, beta = 0.327, P = 0.014), and WASO (R(2) = 0.094, beta = 0.307, P = 0.021) values derived by actigraphy and PSG explaining some of the variability. Using a setting of 10 immobile min for sleep onset yielded a mean SOL that was within 1 min of that estimated by PSG. However SOL values determined by actigraphy and PSG were not significantly correlated at any tested setting. CONCLUSIONS:Our results suggest that actigraphy may be useful for measurement of mean TST, SE, and WASO values in groups of patients with mild to moderate Parkinson's disease. However, there is a significant degree of variability in accuracy among individual patients. The importance of determining optimal scoring parameters for each population studied is underscored.
    背景与目标:
  • 【通过腕部活动描记术,行为反应和多睡眠描记术对睡眠检测的比较。】 复制标题 收藏 收藏
    DOI: 复制DOI
    作者列表:Blood ML,Sack RL,Percy DC,Pen JC
    BACKGROUND & AIMS: Two alternative methods for detecting sleep, wrist actigraphy (ACT) and behavioral response monitoring (BRM), were compared to polysomnography (PSG). In the BRM paradigm, a threshold intensity visual or auditory stimulus generated by a palm-top computer was presented about once per minute, and subjects pressed a microswitch if the stimulus was detected. A response within 5 seconds of the stimulus was scored as "wake" and a failure to respond as "sleep." Four males and four females underwent two nights of simultaneous in-home PSG, BRM, and ACT. Each night, subjects underwent a protocol designed to generate five sleep latency trials. Subjects were awakened by alarm clocks at approximately 1-hour intervals and remained awake for 10 minutes before returning to bed for another sleep onset latency (SOL) trial. Minute-by-minute comparisons were made for PSG versus ACT and BRM. All measures were fairly sensitive in detecting sleep, but BRM was more accurate in determining SOL and subsequent wakefulness. Behavioral response monitoring using a tone resulted in more responses and arousals prior to and during light stages of sleep than BRM using a light. It is concluded that BRM has some important advantages as a simple, minimally invasive method for monitoring sleep.

    背景与目标: 将两种用于检测睡眠的替代方法,腕关节活动描记术 (ACT) 和行为反应监测 (BRM) 与多导睡眠描记术 (PSG) 进行了比较。在BRM范例中,大约每分钟一次呈现由掌上电脑产生的阈值强度视觉或听觉刺激,如果检测到刺激,则受试者按下微动开关。刺激后5秒内的响应被评分为 “唤醒”,而未能响应为 “睡眠”。四名男性和四名女性同时经历了两晚的家庭PSG,BRM和ACT。每天晚上,受试者都会接受一项旨在产生五次睡眠潜伏期试验的协议。受试者每隔约1小时被闹钟唤醒,并保持清醒10分钟,然后返回床上进行另一次睡眠发作潜伏期 (SOL) 试验。对PSG与ACT和BRM进行了每分钟的比较。所有措施在检测睡眠方面都相当敏感,但BRM在确定SOL和随后的清醒方面更为准确。与使用光照的BRM相比,使用音调进行行为反应监测会在睡眠之前和睡眠期间产生更多的反应和唤醒。结论是,BRM作为一种简单,微创的睡眠监测方法具有一些重要的优势。
  • 【用于确定睡眠呼吸障碍儿童的睡眠和觉醒的动作学验证。】 复制标题 收藏 收藏
    DOI:10.1111/j.1365-2869.2007.00588.x 复制DOI
    作者列表:Hyde M,O'Driscoll DM,Binette S,Galang C,Tan SK,Verginis N,Davey MJ,Horne RS
    BACKGROUND & AIMS: :There have been limited studies of the validation of actigraphy for the determination of sleep and wake in children and in this study we aimed to compare wrist actigraphy with polysomnography (PSG). We studied 45 children (29 M/16 F), aged between 1 and 12 years (5.8 +/- 2.7 years, mean +/- SD). Actigraphic data were collected during standard overnight PSG. Data from the actiwatch were analysed over four separate activity threshold settings (low, medium, high, auto). Actigraphic data were compared epoch-by-epoch with the matching PSG. Sleep time was not different from PSG values for the low or auto activity thresholds, but was significantly less on the medium and high activity thresholds (P < 0.05). In contrast, the low and auto activity thresholds significantly underestimated wake time (P < 0.05), whilst that recorded on the medium and high activity thresholds were not different to PSG values. Agreement rates across the thresholds were all high ranging from 85.1% to 88.6%. Predictive value for sleep and sensitivity were also high with values ranging from 91.6% to 94.9% and 90.1% to 97.7%, respectively. In contrast, predictive value for wake and specificity were low ranging between 46.7-65.6% and 39.4-68.9%, respectively. There was no effect of subject age, OAHI or PSG arousal index on AR for any of the activity thresholds. We conclude that actigraphy is a reliable method for determining sleep in children when compared against PSG. Actigraphy may be a useful tool in paediatric sleep clinics and research.
    背景与目标: : 关于确定儿童睡眠和觉醒的动作学验证的研究有限,在这项研究中,我们旨在将手腕动作学与多导睡眠图 (PSG) 进行比较。我们研究了45名儿童 (29 M/16 F),年龄在1至12岁之间 (5.8/- 2.7岁,平均/- SD)。在标准夜间PSG期间收集了活动数据。在四个独立的活动阈值设置 (低,中,高,自动) 上分析了来自actiwatch的数据。活动性数据与匹配的PSG进行了逐个比较。睡眠时间与低或自动活动阈值的PSG值没有差异,但在中高活动阈值上明显较少 (P <0.05)。相反,低活动阈值和自动活动阈值显着低估了唤醒时间 (P <0.05),而在中高活动阈值上记录的唤醒时间与PSG值没有差异。从85.1% 到88.6%,跨阈值的协议率都很高。睡眠和敏感性的预测值也很高,分别为91.6% 至94.9% 和90.1% 至97.7%。相反,唤醒和特异性的预测值分别在46.7-65.6% 和39.4-68.9% 之间较低。对于任何活动阈值,受试者年龄,OAHI或PSG唤醒指数对AR均无影响。我们得出的结论是,与PSG相比,活动描记法是确定儿童睡眠的可靠方法。Actigraphy可能是儿科睡眠诊所和研究中的有用工具。
  • 【睡眠期间的动作和腿部运动: 一项验证研究。】 复制标题 收藏 收藏
    DOI:10.1097/00004691-199903000-00008 复制DOI
    作者列表:Sforza E,Zamagni M,Petiav C,Krieger J
    BACKGROUND & AIMS: A study comparing actigraphy and polysomnography in the detection of leg movements was performed in a group of 35 patients with sleep disorders. Visual scoring used epochs of 5-second duration, and in each epoch, electromyographic activity of tibialis anterior muscle was classified in eight types on the basis of its duration and amplitude. Activity levels of the actigraphic data were logged in 5-second intervals and stored in memory for computer retrieval. To assess the reproducibility of actigraphic detection scoring, in 10 patients actigraphic and polysomnographic data were compared during two consecutive nights. Despite a high correlation between polysomnography and actigraphy in the detection of muscular activity (r = 0.78; P = 0.001), no agreement was obtained between the two analyses according to the Bland and Altman method of concordance (mean bias-117.5). The greater agreement was found for electromyographic activity lasting more than 3 seconds and with an amplitude of more than 50 microV. In the group of patients examined during two consecutive nights the scoring error did not differ significantly. The results demonstrated that (1) despite a significant correlation between actigraphic and polysomnographic data, actigraphy substantially underestimated leg electromyographic activity and therefore could not be used routinely for diagnostic purposes; and (2) because error scoring did not undergo significant changes across the two nights, actigraphy may be used for follow-up evaluation.

    背景与目标: 在一组35名睡眠障碍患者中进行了一项比较运动描记术和多导睡眠描记术检测腿部运动的研究。视觉评分使用5秒持续时间的时间,并且在每个时期,根据其持续时间和幅度将胫骨前肌的肌电图活动分为八种类型。活动数据的活动级别以5秒的间隔记录,并存储在内存中用于计算机检索。为了评估活动检测评分的可重复性,在连续两个晚上比较了10名患者的活动和多睡眠图数据。尽管多导睡眠图和肌动图在肌肉活动检测中具有高度相关性 (r = 0.78; P = 0.001),但根据Bland和Altman一致性方法 (平均偏倚-117.5),两种分析之间没有达成一致。发现肌电图活动持续3秒以上且振幅超过50微伏的一致性更大。在连续两个晚上检查的患者组中,评分错误没有显着差异。结果表明 :( 1) 尽管活动和多导睡眠图数据之间存在显着相关性,但活动图大大低估了腿部肌电活动,因此不能常规用于诊断目的; (2) 由于错误评分在两晚中没有发生重大变化,actigraphy可用于后续评估。
  • 【有和没有睡眠障碍呼吸的青少年使用腕部活动技术进行睡眠估计: 三种数据模式的比较。】 复制标题 收藏 收藏
    DOI:10.1093/sleep/30.7.899 复制DOI
    作者列表:Johnson NL,Kirchner HL,Rosen CL,Storfer-Isser A,Cartar LN,Ancoli-Israel S,Emancipator JL,Kibler AM,Redline S
    BACKGROUND & AIMS: INTRODUCTION:Adolescence is a time of rapid changes in sleep habits and rising prevalence of sleepiness. The importance of measuring sleep in this population is increasingly recognized. In adults, measurements of sleep by actigraphy correlate well with sleep data from EEG recordings. Since actigraphy is increasingly utilized in adolescent sleep studies, more information is needed about reliability in this age group. This analysis investigated which actigraphy data mode is optimal for data collection in adolescents and explored the level of agreement between actigraphy and polysomnography (PSG) in population subgroups. METHODS:181 adolescents aged 12-16 years were concurrently monitored with PSG and wrist actigraphy (measured in 3 data modes: Time Above Threshold [TAT], Zero Crossing Mode [ZCM], and Proportional Integration Mode [PIM]) to measure total sleep time (TST). RESULTS:The sample was 50% male, 55% African American, 9% with sleep disordered breathing (SDB; apnea-hypopnea index > or = 5). Intraclass correlation coefficients (ICC) for TST between actigraphy and PSG were low to moderate and were highest for TAT (0.41) compared to ZCM (0.32) and PIM (0.34). Subgroup analyses revealed that ICCs were higher among those without SDB (0.55) than those with SDB (0.00), and for girls (0.66) compared with boys (0.31). CONCLUSIONS:Results suggest that actigraphy provides a reasonably good estimate of TST in adolescents without SDB. Recognition of the variation in sleep estimates among different data collection modes, among population subgroups, and across the age spectrum, may be of fundamental importance in the interpretation of actigraphy data for sleep duration estimation.
    背景与目标:
  • 11 Actigraphy validation with insomnia. 复制标题 收藏 收藏

    【失眠的活动性验证。】 复制标题 收藏 收藏
    DOI: 复制DOI
    作者列表:Lichstein KL,Stone KC,Donaldson J,Nau SD,Soeffing JP,Murray D,Lester KW,Aguillard RN
    BACKGROUND & AIMS: STUDY OBJECTIVE:Actigraphy, a method of inferring sleep from the presence or absence of wrist movement, has been well validated against polysomnography in trials with people without insomnia. However, the small amount of literature on validation with insomniacs has revealed an actigraphy bias toward overscoring sleep. The current validation trial with insomniacs used the largest number of subjects to date in such research and attracted participants with diverse demographic characteristics. DESIGN:People with insomnia slept 1 night in the laboratory while simultaneously being monitored by polysomnography, actigraphy (high-sensitivity algorithm of the Mini Mitter AW64 Actiwatch), and morning sleep diary. SETTING:Sleep disorders center. PARTICIPANTS:Participants were 57 volunteers from the community, 26 men and 31 women, ranging in age from 21 to 87 years. All participants satisfied conservative criteria for insomnia. The sample included subjects with primary insomnia, subjects with comorbid insomnia, and hypnotic users with current insomnia complaints. INTERVENTIONS:N/A. MEASUREMENTS AND RESULTS:Actigraphy was successfully validated on 4 measures of sleep pattern--number of awakenings, wake time after sleep onset, total sleep time, and sleep efficiency percentage--based on nonsignificant mean differences and significant correlation between actigraphy and polysomnography. Sleep-onset latency with actigraphy was not significantly different from polysomnography but was weakly correlated with polysomnography. Hypnotic use contributed to actigraphic overscoring of sleep. CONCLUSIONS:Actigraphy proved to be a satisfactory objective measure of sleep on 4 of 5 sleep parameters, but these results are specific to this particular instrument using this particular algorithm and should not be construed as a blanket endorsement of actigraphy for measuring insomnia.
    背景与目标:
  • 【作为SSRI激活症状的客观测量方法的一项初步研究: 一项随机安慰剂对照心理药物治疗研究的结果。】 复制标题 收藏 收藏
    DOI:10.1016/j.psychres.2014.11.070 复制DOI
    作者列表:Bussing R,Reid AM,McNamara JP,Meyer JM,Guzick AG,Mason DM,Storch EA,Murphy TK
    BACKGROUND & AIMS: :Selective serotonin reuptake inhibitors (SSRIs) are an efficacious and effective treatment for pediatric obsessive-compulsive disorder (OCD) but have received scrutiny due to a potential side effect constellation called activation syndrome. While recent research introduced a subjective measure of activation syndrome, objective measures have not been tested. This pilot study, using data from a larger randomized-controlled trial, investigated the potential of actigraphy to provide an objective measure of activation symptoms in 44 youths with OCD beginning an SSRI medication regimen. Data were collected over the first four weeks of a multi-site, parallel, double-blind, randomized, placebo controlled psychopharmacological treatment study and statistical modeling was utilized to test how activation syndrome severity predicts daily and nightly activity levels. Results indicated that youths with higher activation symptoms had lower daytime activity levels when treatment averages were analyzed; in contrast youths who experienced onset of activation symptoms one week were more likely to have higher day-time and night-time activity ratings that week. Results support actigraphy as a potential objective measure of activation symptoms. Subsequent studies are needed to confirm these findings and test clinical applications for use by clinicians to monitor activation syndrome during SSRI treatment. National Institutes of Health (5UO1 MH078594-01); NCT00382291.
    背景与目标: : 选择性5-羟色胺再摄取抑制剂 (SSRIs) 是治疗小儿强迫症 (OCD) 的有效方法,但由于潜在的称为激活综合征的副作用而受到审查。尽管最近的研究引入了激活综合征的主观度量,但尚未对客观度量进行测试。这项初步研究使用了一项较大的随机对照试验的数据,研究了在开始SSRI药物治疗方案的44名患有强迫症的年轻人中,激活成像技术提供了客观的激活症状的潜力。在多部位,平行,双盲,随机,安慰剂对照的心理药物治疗研究的前四周收集了数据,并利用统计模型来测试激活综合征的严重程度如何预测每日和每晚的活动水平。结果表明,当分析治疗平均值时,具有较高激活症状的年轻人的白天活动水平较低; 相比之下,一周出现激活症状的年轻人更有可能在该周具有较高的白天和夜间活动评分。结果支持作为激活症状的潜在客观度量。需要随后的研究来证实这些发现并测试临床应用,以供临床医生在SSRI治疗期间监测激活综合征。美国国立卫生研究院 (5UO1 MH078594-01); Nct00382291。
  • 【与多导睡眠描记术相比,通过激活描记术进行的PLM检测: 两种激活描记术的验证和比较。】 复制标题 收藏 收藏
    DOI:10.1016/j.sleep.2008.03.015 复制DOI
    作者列表:Gschliesser V,Frauscher B,Brandauer E,Kohnen R,Ulmer H,Poewe W,Högl B
    BACKGROUND & AIMS: OBJECTIVE:To compare periodic leg movement (PLM) counts obtained with polysomnography (PSG) to those obtained from actigraphy with two devices (Actiwatch and PAM-RL). METHODS:Twenty-four patients underwent full night actigraphy with Actiwatch from both legs and simultaneous PSG. Out of these patients, 10 had additional actigraphy with PAM-RL. Bilateral and unilateral PLM indices (PLMI) for both actigraphs were calculated for time in bed and compared to polysomnographic PLMI. Additionally, a comparison between the two different actigraphs was performed. RESULTS:PLMI obtained with Actiwatch were significantly lower than those obtained with PSG (21.2+/-25.6/h versus 34.4+/-30.7/h; p<0.001), whereas the PLMI from PAM-RL were significantly higher than in PSG (63.6+/-39.3/h versus 37.0+/-33.5/h; p=0.009). In direct comparison, Actiwatch gave significantly lower PLMI than the PAM-RL (p=0.005). The correlations between Actiwatch and PSG (rho=0.835, p<0.001), PAM-RL and PSG (rho=0.939, p<0.001), and Actiwatch and PAM-RL (rho=0.915, p<0.001) were significant. Unilateral actigraphy compared to standard PSG gave less consistent findings. When comparing different settings of the PAM-RL, manual threshold setting resulted in PLMI that were no longer different from PSG (p=0.074), in contrast to the default threshold setting. CONCLUSIONS:The Actiwatch underestimated and the PAM-RL overestimated PLMI compared to PSG. Whereas PLMI obtained with two actigraphs and PSG were highly correlated, they differed in mean values. Therefore, PSG, actigraphy and also the different actigraphs cannot be interchanged in longitudinal studies, and actigraphy should not be used for diagnostic decision making based on PLM indices. The best approximation to PSG PLMI was achieved by using manual threshold setting with the PAM-RL.
    背景与目标:
  • 【创伤后应激障碍 (PTSD) 的睡眠障碍: 对活动学研究的系统评价和荟萃分析。】 复制标题 收藏 收藏
    DOI:10.1080/20008198.2020.1767349 复制DOI
    作者列表:Lewis C,Lewis K,Kitchiner N,Isaac S,Jones I,Bisson JI
    BACKGROUND & AIMS: Background:Sleep disturbance has been described as a 'hallmark' symptom of posttraumatic stress disorder (PTSD). Although there are robust findings of self-reported sleep disturbance in PTSD, evidence of sleep disturbance measured using actigraphy is less certain. Objective:To conduct a systematic review and meta-analysis to determine whether there are any significant differences between individuals with and without PTSD in actigraph-derived sleep measures. Method:Case-control studies comparing participants with current PTSD to those without PTSD were eligible for inclusion. Sleep parameters of interest were: (1) total sleep time; (2) sleep onset latency; (3) wake after sleep onset (WASO); and (4) sleep efficiency. Data were meta-analysed as standardised mean differences (SMDs) and potential sources of heterogeneity were explored through meta-regression. Six actigraphy studies with 405 participants were included. Results:There was no evidence of a statistically significant difference between those with and without PTSD in total sleep time (SMD 0.09, 95%CI -0.23 to 0.42); WASO (SMD 0.18, 95%CI -0.06 to 0.43); sleep latency (SMD 0.32, 95%CI -0.04 to 0.69); or sleep efficiency (SMD -0.28, 95%CI -0.78 to 0.21). Conclusions:Further high-quality research is required to determine whether there is a true difference in sleep between those with and without PTSD. :Antecedentes: La perturbación del sueño se ha descrito como un síntoma ‘distintivo’ del trastorno de estrés postraumático (TEPT). Aunque existen hallazgos sólidos de trastornos del sueño en el TEPT a través de auto-reportes, la evidencia de éstos medidos con el uso de actigrafía es más incierta.Objetivo: Realizar una revisión sistemática y un metanálisis para determinar si hay diferencias significativas entre los individuos con y sin TEPT en medidas de sueño derivadas de la actigrafía.Método: Los estudios de casos y controles incluidos como elegibles fueron aquéllos que compararon participantes con TEPT en curso con aquellos participantes sin TEPT. Los parámetros de sueño de interés fueron: (1) tiempo total del sueño; (2) latencia del inicio del sueño; (3) vigilia después del inicio de sueño (wake after sleep onset, WASO, en su sigla en inglés); y (4) eficiencia del sueño. Los datos fueron meta-analizados como diferencias de medias estandarizadas (DME) y se exploraron las posibles fuentes de heterogeneidad mediante metarregresión. Se incluyeron seis estudios de actigrafía con 405 participantes.Resultados: No hubo evidencia de una diferencia estadísticamente significativa entre aquellos con y sin TEPT en el tiempo total del sueño (DME 0.09, IC 95%: −0,23 a 0,42); WASO (DME 0.18, IC 95% −0.06 a 0.43); latencia del sueño (SMD 0.32, IC 95% −0.04 a 0.69); o eficiencia del sueño (SMD −0.28, IC 95% −0.78 a 0.21).Conclusiones: Se requieren futuras investigaciones de alta calidad para determinar si existe una verdadera diferencia en el sueño entre aquéllos con y sin TEPT. :背景: 睡眠障碍被描述为创伤后应激障碍 (PTSD) 的‘标志’症状。尽管在PTSD中有自我报告的睡眠障碍的强有力的发现, 但使用活动记录仪测量的睡眠障碍的证据尚不确定。目的: 进行系统综述和元分析, 以确定在有或没有患有创伤后应激障碍的个体中, 从活动记录仪进行的睡眠测量之间是否存在显著差异。方法: 将有患有PTSD与没有PTSD的参与者进行比较的病例-对照研究纳入。关注的睡眠参数为: (1) 总睡眠时间 (2) 睡眠潜伏期 (3) 入睡后醒来 (WASO) (4) 睡眠效率。对数据的标准均值差 (SMD) 进行元分析, 并通过探索潜在的异质性来源。共纳入包括405名参与者的六项活动记录仪研究。结果: 没有证据表明有PTSD的人和没有PTSD的人的总睡眠时间有统计学差异 (SMD 0.09, 95%CI −0.23至0.42) ; WASO (SMD 0.18, 95%CI −0.06至0.43);睡眠潜伏期 (SMD 0.32, 95%CI −0.04至0.69);或睡眠效率 (SMD −0.28, 95%CI −0.78至0.21) 。结论: 需要进行进一步的高质量研究, 以确定是否患有PTSD的人在睡眠方面是否存在真正的差异。.
    背景与目标:
  • 【Smith-Magenis综合征儿童的睡眠: 一项病例对照动作学研究。】 复制标题 收藏 收藏
    DOI:10.1093/sleep/zsz260 复制DOI
    作者列表:Trickett J,Oliver C,Heald M,Denyer H,Surtees A,Clarkson E,Gringras P,Richards C
    BACKGROUND & AIMS: STUDY OBJECTIVES:The objectives of the study were (1) to compare both actigraphy and questionnaire-assessed sleep quality and timing in children with Smith-Magenis syndrome (SMS) to a chronologically age-matched typically developing (TD) group and (2) to explore associations between age, nocturnal and diurnal sleep quality, and daytime behavior.

    METHODS:Seven nights of actigraphy data were collected from 20 children with SMS (mean age 8.70; SD 2.70) and 20 TD children. Daily parent/teacher ratings of behavior and sleepiness were obtained. Mixed linear modeling was used to explore associations between total sleep time and daytime naps and behavior.

    RESULTS:Sleep in children with SMS was characterized by shorter total sleep time (TST), extended night waking, shorter sleep onset, more daytime naps, and earlier morning waking compared to the TD group. Considerable inter-daily and inter-individual variability in sleep quality was found in the SMS group, so caution in generalizing results is required. An expected inverse association between age and TST was found in the TD group, but no significant association was found for the SMS group. No between-group differences in sleep hygiene practices were identified. A bidirectional negative association between TST and nap duration was found for the SMS group. In the SMS group, increased afternoon sleepiness was associated with increased irritability (p = .007) and overactivity (p = .005).

    CONCLUSION:These findings evidence poor sleep quality in SMS and the need to implement evidence-based interventions in this population.

    背景与目标: 学习目标 : 该研究的目的是 (1) 将史密斯-马格尼斯综合征 (SMS) 儿童的活动记录和问卷评估的睡眠质量和时间与年龄匹配的典型发育 (TD) 组进行比较; (2) 探索年龄,夜间和昼夜睡眠质量之间的关联,和白天的行为。
    方法 : 从20名SMS儿童 (平均年龄8.70岁; SD 2.70岁) 和20名TD儿童中收集了七个晚上的活动记录数据。获得了父母/老师对行为和嗜睡的每日评分。混合线性模型用于探索总睡眠时间与白天小睡和行为之间的关联。
    结果 : SMS儿童的睡眠特征是总睡眠时间 (TST) 较短,夜间清醒时间延长,睡眠发作时间缩短,与TD组相比,白天小睡更多,早上醒来更多。在SMS组中发现睡眠质量存在相当大的日常和个体间差异,因此在概括结果时需要谨慎。在TD组中发现了年龄与TST之间的预期反向关联,但在SMS组中未发现显着关联。未发现睡眠卫生习惯的组间差异。对于SMS组,发现TST和nap持续时间之间存在双向负相关。在SMS组中,下午嗜睡增加与烦躁 (p = .007) 和过度活跃 (p = .005) 有关。
    结论 : 这些发现表明SMS的睡眠质量较差,并且需要在该人群中实施循证干预措施。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录