BACKGROUND & AIMS:
:Previously, we reported that gabapentin, a lambda-aminobutyric acid (GABA) agonist, significantly reduced "positive" subjective effects of cocaine without reducing cocaine self-administration. We speculated that the gabapentin doses used in that study were too low to detect subtle shifts in the reinforcing effects of cocaine. Thus, the present study examined the effects of larger gabapentin maintenance doses on cocaine-related effects, including self-administration. During this 48-day double-blind, crossover design study, the effects of gabapentin maintenance (0, 2400, 3200 mg/day) on response to cocaine (0, 12, 25, 50 mg) were investigated in six cocaine-dependent individuals not seeking treatment for their cocaine use. Active cocaine significantly increased choice to self-administer cocaine, subjective-effect ratings (e.g., "Good Drug Effect"), blood pressure, and heart rate. Gabapentin did not decrease cocaine self-administration, cardiovascular measures, or most subjective effects of cocaine. These data agree with findings from a clinical trial examining the effects of similar gabapentin doses on cocaine use by treatment-seeking cocaine-dependent individuals and suggest that gabapentin does not show promise as a treatment medication for cocaine dependence.
背景与目标:
: 以前,我们报道了加巴喷丁,一种 λ-氨基丁酸 (GABA) 激动剂,在不减少可卡因自我给药的情况下显着降低了可卡因的 “积极” 主观作用。我们推测该研究中使用的加巴喷丁剂量太低,无法检测可卡因增强作用的细微变化。因此,本研究检查了较大的加巴喷丁维持剂量对可卡因相关作用 (包括自我给药) 的影响。在这项为期48天的双盲,交叉设计研究中,在六个可卡因依赖者中研究了加巴喷丁维持 (0、2400、3200 mg/天) 对可卡因 (0、12、25、50 mg) 的反应的影响。不寻求可卡因使用治疗的个体。活性可卡因显着增加了自我管理可卡因的选择,主观效果等级 (例如 “良好的药物效果”),血压和心率。加巴喷丁没有减少可卡因的自我给药,心血管措施或可卡因的最主观影响。这些数据与一项临床试验的结果一致,该试验研究了类似加巴喷丁剂量对寻求可卡因依赖的个体使用可卡因的影响,并表明加巴喷丁没有显示出可卡因依赖的治疗药物的希望。