152 patients with thromboangiitis obliterans (Buerger's disease) and pain from critical leg ischaemia were randomly allocated to receive iloprost, a chemically stable prostacyclin analogue, or low-dose aspirin, for 28 days in a double-blind trial. On review, 19 patients did not fulfil the stringent entry criteria. Of the other 133 patients, 98 also had leg ulcers. After 21-28 days, 58 (85%) of 68 iloprost-treated patients showed ulcer healing or relief of ischaemic pain, compared with 11 (17%) of 65 in the aspirin-treated group. 43 (63%) on iloprost treatment had complete relief of pain, compared with 18 (28%) on aspirin. Ulcers healed completely in 18 of 52 (35%) who received iloprost compared with 6 of 46 (13%) who received aspirin. 6 months after the start of treatment, the response rate was 45 of 51 (88%) patients treated with iloprost compared with 12 of 44 (21%) patients treated with aspirin.
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【Trial of iloprost versus aspirin treatment for critical limb ischaemia of thromboangiitis obliterans. The TAO Study.].
【伊洛前列素与阿司匹林治疗闭塞性血栓血管炎的严重肢体缺血的试验。 TAO研究。】
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DOI：10.1016/0140-6736(90)90346-7文章类型：杂志文章
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在双盲试验中，将152名患有闭塞性血栓性血管炎（Buerger病）和因严重下肢缺血的疼痛的患者随机分配接受伊洛前列素（伊洛前列素），伊洛前列素是一种化学稳定的前列环素类似物或小剂量阿司匹林。经复查，有19名患者不符合严格的入院标准。在其他133名患者中，有98名还患有腿部溃疡。 21-28天后，接受伊洛前列素治疗的68位患者中有58位（85％）溃疡愈合或减轻了缺血性疼痛，而阿司匹林治疗组的65位中有11位（17％）。伊洛前列素治疗组中有43（63％）名患者完全缓解了疼痛，而阿司匹林治疗组中只有18（28％）名。接受伊洛前列素的52名患者中有18名（35％）的溃疡完全治愈，而接受阿司匹林的46名患者中有6名（13％）的溃疡得到了完全治愈。在开始治疗后的6个月，伊洛前列素治疗的51例患者中有45例（88％）有效率，而阿司匹林治疗的44例患者中有12例（21％）有效率。
