OBJECTIVE:To determine whether eosinophil-derived neurotoxin (EDN) is a predictive marker of recurrent wheezing episodes in post-respiratory syncytial virus (RSV) bronchiolitis.
METHODS:EDN levels and recurrent wheezing episodes were serially measured in 200 infants hospitalized with RSV bronchiolitis.
RESULTS:Serum EDN levels at 3 months correlated significantly with total wheezing episodes at 12 months in the RSV-PLC (n = 71; r = 0.720, p < 0.0001) and RSV-MONT groups (n = 79; r = 0.531, p < 0.001). Positive predictive value of 3-mo EDN level for total wheezing episodes was 57%; negative predictive value, 76%; sensitivity, 72%; specificity, 62%.
CONCLUSION:EDN levels have predictive value for the development of recurrent wheezing post-RSV bronchiolitis.
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【Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing.].
【呼吸道合胞病毒细支气管炎后3个月，嗜酸性粒细胞来源的神经毒素水平是反复性喘息的预测生物标志物。】
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DOI：10.3109/1354750X.2013.773078文章类型：杂志文章
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目的：确定嗜酸性粒细胞源性神经毒素（EDN）是否是呼吸道合胞病毒（RSV）细支气管炎反复喘息发作的预测指标。
方法：连续测量200例RSV细支气管炎住院婴儿的EDN水平和反复喘息发作。
结果：RSV-PLC（n = 71; r = 0.720，p <0.0001）和RSV-MONT组（n = 79; r = 0.531，p）在3个月时的血清EDN水平与12个月时总的喘息发作显着相关<0.001）。 EDN水平3个月对总的喘息发作的阳性预测值为57％；阴性预测值，占76％；敏感度为72％；特异性为62％。
结论：EDN水平对RSV后细支气管炎复发性喘息的发生具有预测价值。
方法：连续测量200例RSV细支气管炎住院婴儿的EDN水平和反复喘息发作。
结果：RSV-PLC（n = 71; r = 0.720，p <0.0001）和RSV-MONT组（n = 79; r = 0.531，p）在3个月时的血清EDN水平与12个月时总的喘息发作显着相关<0.001）。 EDN水平3个月对总的喘息发作的阳性预测值为57％；阴性预测值，占76％；敏感度为72％；特异性为62％。
结论：EDN水平对RSV后细支气管炎复发性喘息的发生具有预测价值。
