Community-acquired Clostridium difficile infection (CA-CDI) is a growing concern. CA-CDI differs from hospital-acquired C. difficile infection (HA-CDI) in its epidemiology, risk factors, severity, and outcomes. In this study, we investigated C. difficile infections in a tertiary care hospital in Seoul, Korea, and compared the CA-CDI and HA-CDI cases diagnosed in the same period. Total 593 cases were confirmed as CDI in 2014, of which CA-CDI accounted for 68 (11.5%) of the total CDI cases. Compared with HA-CDI, the mean age of CA-CDI cases was lower than that of HA-CDI (42.7 vs 60.4). In CA-CDI, antibiotic and proton pump inhibitor (PPI) use in the 12 preceding weeks and concurrent chemotherapy and tube feeding were less frequent compared with HA-CDI. In most cases (63/68, 92.6%), patients with CA-CDI recovered without any complications or recurrence. The most prevalent C. difficile type in CA-CDI cases was PCR-ribotype 012, accounting for 18.3% of the total, followed by PCR-ribotype 018 (16.7%).
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【Clinical and molecular characteristics of community-acquired Clostridium difficile infections in comparison with those of hospital-acquired C. difficile.].
【社区获得性艰难梭菌感染与医院获得性艰难梭菌感染的临床和分子特征。】
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DOI：10.1016/j.anaerobe.2017.06.014文章类型：杂志文章
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社区获得性艰难梭菌感染 (ca-cdi) 日益受到关注。Ca-cdi与医院获得性艰难梭菌感染 (ha-cdi) 的流行病学、危险因素、严重程度和结局不同。在这项研究中，我们调查了韩国首尔一家三级医院的艰难梭菌感染，并比较了同期诊断的ca-cdi和ha-cdi病例。共593例确诊为CDI 2014年，其中ca-cdi占CDI病例总数的68 (11.5%)。与ha-cdi相比，ca-cdi病例的平均年龄低于ha-cdi (42.7 vs 60.4)。在ca-cdi中，与ha-cdi相比，前12周使用抗生素和质子泵抑制剂 (PPI) 以及同时进行化疗和管饲的频率较低。在大多数情况下 (63/68，92.6%)，CA-CDI患者恢复无任何并发症或复发。CA-CDI病例中最普遍的艰难梭菌类型是PCR核型012，占总数的18.3%，其次是PCR核型018 (16.7%)。
