BACKGROUND AND PURPOSE:Scleroderma is an immune-mediated disease characterized by excess deposition of collagen leading to microvascular occlusion. Morbidity and mortality are often secondary to pulmonary hypertension from injury to pulmonary microvasculature and interstitial lung disease. This study correlated P-wave findings on the 12-lead electrocardiogram (ECG) with mean pulmonary artery pressure (mPAP) measured by right heart catheterization in patients with scleroderma.
METHODS:A retrospective review of 12-lead ECGs in 23 patients referred to a rheumatology clinic with the diagnosis of scleroderma was performed. Right heart catheterization was performed within 1 month of the resting ECG.
RESULTS:Linear regression related P-wave amplitude in lead II with mPAP (r = 0.52, P = .011) This model was 73% sensitive and 67% specific for the presence or absence of elevated mPAP.
CONCLUSIONS:P-wave amplitude analysis on the ECG may be helpful in the assessment of pulmonary hypertension in patients with scleroderma.
-
【P-wave amplitude and pulmonary artery pressure in scleroderma.].
【硬皮病中的P波振幅和肺动脉压。】
复制标题
收藏
DOI：10.1016/j.jelectrocard.2006.01.004文章类型：杂志文章
复制DOI
译文
背景与目的：硬皮病是一种免疫介导的疾病，其特征是胶原蛋白的过度沉积导致微血管闭塞。发病率和死亡率通常是继发于肺动脉高压的疾病，从损伤到肺微脉管系统和间质性肺疾病。这项研究将硬皮病患者的12导联心电图（ECG）上的P波发现与右心导管检查测得的平均肺动脉压（mPAP）相关联。
方法：回顾性分析23例转诊至风湿病诊所并诊断为硬皮病的患者的12导联心电图。静息ECG后1个月内进行右心导管检查。
结果：与mPAP的铅II线性回归相关的P波振幅（r = 0.52，P = .011）该模型对存在或不存在mPAP升高的敏感性为73％，特异性为67％。
结论：心电图的P波振幅分析可能有助于评估硬皮病患者的肺动脉高压。
方法：回顾性分析23例转诊至风湿病诊所并诊断为硬皮病的患者的12导联心电图。静息ECG后1个月内进行右心导管检查。
结果：与mPAP的铅II线性回归相关的P波振幅（r = 0.52，P = .011）该模型对存在或不存在mPAP升高的敏感性为73％，特异性为67％。
结论：心电图的P波振幅分析可能有助于评估硬皮病患者的肺动脉高压。
