Obesity and nutrients intake deficiencies may contribute to the clinical manifestations and inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was to assess the relationship between nutritional status and dietary intake with clinical variables in Mexican-mestizo SLE patients. A cross-sectional study was conducted in 130 female SLE patients, classified by the 1997 SLE American College of Rheumatology (ACR) criteria; the clinical activity was evaluated by the Mexican-Systemic Lupus Erythematosus-Disease Activity Index (Mex-SLEDAI); body mass index (BMI) by the World Health Organization (WHO) criteria; the energy calculation and nutritional intake were performed by Nutritionist Pro Diet software. SLE patients with excess weight (BMI > 25 kg/m2) showed a higher score of clinical activity (Mex-SLEDAI = 2; p = 0.003), higher clinical activity prevalence (40.9%; p = 0.039) and a significant association for high clinical activity (odds ratio (OR) = 2.52; 95% confidence interval (CI) = 1.08-5.9; p = 0.033), in comparison with patients without excess weight (BMI < 25 kg/m2). In particular, the excess weight increased the Mex-SLEDAI score (β coefficient = 1.82; R2 = 0.05; p = 0.005). Also, the SLE patients presented a high prevalence (%) of deficient consumption (cut-off point: <67% of dietary adequacy) of vitamin E (100%), iodine (96%), omega 3 (93.44%), biotin (78%), vitamin K (73.33%), iron (67%), vitamin D (63.3%), potassium (59%), folic acid (56.67%), pantothenic acid (43.3%), vitamin A (41.67%) and zinc (32%). In conclusion, in SLE patients the excess weight was associated with increased clinical activity and to the presence of deficiencies in some essential nutrients ingested.
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【Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients.].
【系统性红斑狼疮患者超重与临床活动和饮食摄入不足的关系。】
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DOI：10.3390/nu11112683文章类型：杂志文章
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：肥胖和营养摄入不足可能会导致系统性红斑狼疮（SLE）的临床表现和炎症过程。这项研究的目的是评估墨西哥中间型SLE患者的营养状况和饮食摄入与临床变量之间的关系。根据1997年SLE美国风湿病学会（ACR）标准对130位女性SLE患者进行了横断面研究。临床活性通过墨西哥系统性红斑狼疮-疾病活性指数（Mex-SLEDAI）进行评估；根据世界卫生组织（WHO）的标准确定的体重指数（BMI）；能量计算和营养摄入量由Nutritionist Pro Diet软件执行。体重过重（BMI> 25 kg / m2）的SLE患者表现出较高的临床活动评分（Mex-SLEDAI = 2; p = 0.003），较高的临床活动患病率（40.9％; p = 0.039）并与高活动度显着相关与没有体重过重（BMI <25 kg / m2）的患者相比，临床活动（比值（OR）= 2.52； 95％置信区间（CI）= 1.08-5.9； p = 0.033）。特别是，超重增加了Mex-SLEDAI得分（β系数= 1.82； R2 = 0.05； p = 0.005）。此外，SLE患者的维生素E（100％），碘（96％），欧米伽3（93.44％），生物素的摄入不足（临界值：<饮食充足的67％）的患病率较高（％） （78％），维生素K（73.33％），铁（67％），维生素D（63.3％），钾（59％），叶酸（56.67％），泛酸（43.3％），维生素A（41.67％ ）和锌（32％）。总之，在SLE患者中，超重与增加的临床活动以及摄入的某些必需营养素缺乏有关。
