BACKGROUND & AIMS:
OBJECTIVE:Increased C3 has been related to body mass index (BMI) and insulin resistance, although there are not sufficient studies in subjects with morbid obesity. The purpose of this study was to evaluate the levels of C3 as a function of the BMI in subjects of both sexes, with severe, morbid and extreme obesity, and their possible relationship to insulin resistance or associated diseases such as diabetes, hypertension and dyslipidemia.
SUBJECTS:The study included a total of 316 patients (110 men and 206 women) with severe obesity (17.1%), morbid obesity (54.4%) and extreme obesity (28.4%), with an average BMI of 46.70+/-7.37 kg/m2.
MEASUREMENTS:The glucose and insulin levels were determined baseline, and 2 h after a 75 g of oral glucose load. The homeostasis model of assessment for insulin resistance (HOMA-IR) was calculated. A lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B100) was obtained and C3 levels determined by nephelometry.
RESULTS:When distributing the patients by quartiles of BMI, we found a progressive increase in the levels of C3, and no significant differences in the rest of analytical variables studied were found; the mean values of C3 were 127.78+/-29.7 mg/dl.A significant correlation was found between C3 and the BMI (r=0.263, P<0.001), baseline insulin (r=0.237, P=0.001) and HOMA-IR (r=0.237, P=0.001). High blood pressure was found in 111 patients, type 2 diabetes in 74 patients and dyslipidemia in 139 cases. When distributing the levels of C3 according to the number of associated risk factors (hypertension, diabetes and dyslipidemia), we found significant differences between these patients and those who presented no associated diseases (P<0.01).
CONCLUSION:A relationship between C3 and the progressive increase of BMI in subjects with severe, morbid or extreme obesity was established. This increase in C3 was closely related to insulin levels and the values for HOMA-IR. Furthermore, we also found an increase in C3 as more diseases related to insulin resistance, such as diabetes, hypertension and dyslipidemia, were associated with the obesity.
背景与目标:
目的:尽管对于病态肥胖的受试者尚无足够的研究,但C3升高与体重指数(BMI)和胰岛素抵抗有关。这项研究的目的是评估患有严重,病态和极端肥胖的男女受试者中C3水平与BMI的关系,以及它们与胰岛素抵抗或相关疾病如糖尿病,高血压和血脂异常的可能关系。
研究对象:该研究共纳入316例重度肥胖(17.1%),病态肥胖(54.4%)和极度肥胖(28.4%)的患者(110例男性和206例女性),平均BMI为46.70 /-7.37 kg /平方米
测量:血糖和胰岛素水平是在基线时以及口服75 g葡萄糖后2小时确定的。计算了胰岛素抵抗评估的稳态模型(HOMA-IR)。获得脂质概况(总胆固醇,甘油三酸酯,高密度脂蛋白胆固醇,载脂蛋白AI和载脂蛋白B100),并通过浊度法测定C3水平。
结果:当按BMI的四分位数分配患者时,我们发现C3的水平逐渐升高,其余研究分析变量均无显着差异。 C3的平均值为127.78 /-29.7 mg / dl.C3与BMI(r = 0.263,P <0.001),基线胰岛素(r = 0.237,P = 0.001)和HOMA-IR之间存在显着相关性r = 0.237,P = 0.001)。高血压患者111例,2型糖尿病74例,血脂异常139例。当根据相关危险因素(高血压,糖尿病和血脂异常)的数量分配C3水平时,我们发现这些患者与没有相关疾病的患者之间存在显着差异(P <0.01)。
结论:在重度,病态或极度肥胖的受试者中,C3与BMI的进行性增加之间存在关系。 C3的增加与胰岛素水平和HOMA-IR值密切相关。此外,我们还发现C3升高,因为与胰岛素抵抗相关的更多疾病(例如糖尿病,高血压和血脂异常)与肥胖有关。