Breast density is widely adopted to reflect the likelihood of early breast cancer development. Existing methods of mammographic density classification either require steps of manual operations or achieve only moderate classification accuracy due to the limited model capacity. In this study, we present a radiomics approach based on dilated and attention-guided residual learning for the task of mammographic density classification. The proposed method was instantiated with two datasets, one clinical dataset and one publicly available dataset, and classification accuracies of 88.7% and 70.0% were obtained, respectively. Although the classification accuracy of the public dataset was lower than the clinical dataset, which was very likely related to the dataset size, our proposed model still achieved a better performance than the naive residual networks and several recently published deep learning-based approaches. Furthermore, we designed a multi-stream network architecture specifically targeting at analyzing the multi-view mammograms. Utilizing the clinical dataset, we validated that multi-view inputs were beneficial to the breast density classification task with an increase of at least 2.0% in accuracy and the different views lead to different model classification capacities. Our method has a great potential to be further developed and applied in computer-aided diagnosis systems.

译文

乳房密度被广泛采用,以反映早期乳腺癌发展的可能性。由于模型容量有限,现有的乳房x线密度分类方法要么需要手动操作步骤,要么仅达到中等的分类精度。在这项研究中,我们提出了一种基于扩张和注意力引导的残差学习的放射组学方法,用于乳房x线摄影密度分类。将所提出的方法实例化为两个数据集,一个临床数据集和一个公开数据集,并分别获得了88.7% 和70.0% 的分类精度。尽管公共数据集的分类精度低于临床数据集,这很可能与数据集大小有关,但我们提出的模型仍然比朴素残差网络和最近发布的几种基于深度学习的方法取得了更好的性能。此外,我们设计了一种专门针对分析多视图乳房x线照片的多流网络体系结构。利用临床数据集,我们验证了多视图输入对乳房密度分类任务有益,其准确性至少提高了2.0%,并且不同的视图导致了不同的模型分类能力。我们的方法具有很大的潜力,可以在计算机辅助诊断系统中进一步开发和应用。

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