BACKGROUND & AIMS:
OBJECTIVE:To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these.
METHODS AND RESULTS:Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for.
CONCLUSIONS:Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.
背景与目标:
目的:研究年龄相关的循环炎症介质浓度增加是由于心血管危险因素的同时发生还是与之无关。
方法和结果:细胞因子(IL-6,IL-18),趋化因子(6Ckine,MCP-1,IP-10),可溶性粘附分子(sICAM-1,sVCAM-1,sE-selectin)和脂联素(adiponectin)是在18-84岁的健康男性受试者的血浆中测量(n = 162)。这些与已知的心血管危险因素(年龄,BMI,收缩压和舒张压,血浆总胆固醇,LDL胆固醇,HDL胆固醇和三酰甘油浓度)相关,以便确定显着的相关性。 sVCAM-1,sE-选择素,IL-6,IL-18,MCP-1、6Ckine,IP-10和脂联素的血浆浓度与年龄以及其他几个因素呈显着正相关心血管危险因素。当控制年龄时,与其他危险因素的相关性就消失了。相反,在控制其他心血管危险因素的情况下,sVCAM-1,IL-6,MCP-1、6Ckine和IP-10与年龄的相关性仍然很显着。
结论:某些炎症标记物(sVCAM-1,IL-6,MCP-1、6Ckine,IP-10)的血浆浓度与年龄呈正相关,而与其他心血管危险因素无关。这表明与年龄有关的炎症可能不是由公认的危险因素驱动的。