This paper supports a thesis on control of chemical systems occurring in metabolism which makes extensive use of energy forms with an indirect or vicarious route to their targets in the chemicals concerned. In the recent decade or so, quantum chemists in studying the same problem, control of chemical reactions by indirect routes, not necessarily with a specific bio-function goal, have produced almost identical protocols known as quantum sculpting of the chemical wave function in their laboratory experiments. Parallels and modulations of the two approaches, native and man-made, are discussed in this paper with the aim of supporting the hypothesis at a level displaying high rationale for an intransigent aspect of physical chemistry of eventual clinical implication, that of control of complex chemical systems.