The hypothesis that only melanosomal catecholic amino acids contribute to melanin formation was tested by studying adult bovine eyes in which pigment synthesis is considered to be low or absent. Dopa and 5-S-cysteinyldopa were investigated in different cell fractions of the choroid and retinal pigment epithelium of cattle. Most of the dopa and 5-S-cysteinyldopa was found in the cytoplasm and very little in the large granule fraction. The presence of cysteinyldopa in the adult eye is evidence of tyrosinase activity, but the catechol amino acids in the cytoplasm probably do not give rise to melanin formation. It is assumed that they instead are excreted from the cells.

译文

通过研究认为色素合成低或缺乏的成年牛眼,检验了只有黑色素体儿茶酸氨基酸有助于黑色素形成的假说。在牛的脉络膜和视网膜色素上皮的不同细胞部分中研究了多巴和5-s-半胱氨酰多巴。大多数多巴和5-s-半胱氨酰多巴在细胞质中发现,而在大颗粒部分中很少发现。成年眼睛中半胱氨酰多巴的存在是酪氨酸酶活性的证据,但是细胞质中的邻苯二酚氨基酸可能不会引起黑色素的形成。假设它们是从细胞中排泄出来的。

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