The aim of this study was to assess the clinical value of serum oestradiol concentration 8 days after embryo transfer (D8E2) and beta-human chorionic gonadotrophin (HCG-beta) concentration 12 days after embryo transfer (D12HCG-beta) in the prediction of pregnancy and the outcome of pregnancy following assisted reproduction, taking into account the day of transfer, which was either day 3 (D3) or day 5 (D5). The objective was to improve patient counselling by giving quantitative and reliable predictive information instead of non-specific uncertainties. A total of 2035 embryo transfer cycles performed between January 2003 and June 2005 were analysed retrospectively. Biochemical pregnancy, ectopic pregnancy and first-trimester abortions were classified as non-viable pregnancies; pregnancies beyond 12 weeks gestation were classified as ongoing pregnancies (OP). Significantly higher D8E2 and D12HCG-beta were obtained in D5 transfers compared with D3 transfers with regard to pregnancy and OP (P
译文
本研究的目的是评估胚胎移植后8天血清雌二醇浓度 (D8E2) 和胚胎移植后12天 β-人绒毛膜促性腺激素 (HCG-β) 浓度 (D12HCG-beta) 在预测妊娠和辅助生殖后妊娠结局中的临床价值，考虑到转移的日期，即第3天 (D3) 或第5天 (D5)。目的是通过提供定量和可靠的预测信息而不是非特异性不确定性来改善患者咨询。回顾性分析了2003年1月和2005年6月之间进行的2035年胚胎移植周期。生化妊娠，异位妊娠和早孕流产被归类为不可行妊娠; 妊娠12周以上的妊娠被归类为持续妊娠 (OP)。就妊娠和OP而言，与D3转移相比，D5转移获得了明显更高的D8E2和D12HCG-beta (P <或 = 0.001)。对于D3胚胎移植，D8E2预测OP的临界值为130 pg/ml (敏感性80%，特异性72%)，而D12HCG-beta为98 mIU/ml (敏感性89%，特异性69%)。对于D5胚胎移植，分别为179 pg/ml (敏感性79%，特异性84%) 和257 mIU/ml (敏感性78%，特异性81%)。看来，胚胎移植后血清D8E2和D12HCG-beta浓度提供了有关IVF胚胎移植后妊娠和妊娠结局的明确信息。
