肿瘤
词汇介绍
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解析
Dose 英 /dəʊs/ 美 /dos/
释 义 n. 剂量;一剂,一服;vi. 服药;vt. 给药;给…服药;n. (Dose)人名;(德)多泽;(意、西、葡、塞)多塞;(英)多斯;
同根词 dosage n. 剂量,用量
dosing n. 定量给料,配量;精密分注
dosimetry n. [临床] 剂量学;放射量测定
例 句 You and your doctor will discuss what dose is right for you. 你需和你的医生讨论什么剂量是最适合你的。
Limiting 英 /'lɪmɪtɪŋ/ 美 /'lɪmɪtɪŋ/
释 义 adj. 限制的,局限的;限制性的,制约的;v. 限制;限定(limit 的现在分词)
同根词 limited adj. 有限的
limitless adj. 无限制的;无界限的
limit n. 限制;限度;界线
limited n. 高级快车
limitation n. 限制;限度;极限;追诉时效;有效期限
limiter n. [机][电] 限制器,[电子] 限幅器;限制者
limit vt. 限制;限定
例 句 In order to be infinite beings, we must have no desires because any desire is a limiting action upon -ourselves. 为了成为无限的存在,我们必须没有任何欲望,因为欲望是对我们自己的限制。
Toxicity 英 /tɒk'sɪsətɪ/ 美 /tɑk'sɪsəti/
释 义 n. [毒物] 毒性;复数 toxicities
同根词 toxic adj. 有毒的;中毒的
toxicologic adj. 毒物学的;毒素的
toxicology n. [毒物] 毒物学,[毒物] 毒理学
toxicologist n. 毒理学家
例 句 Should a lab be so fortunateas to discover a molecule that cures a disease in a lab rat, the next step isto test its toxicity and efficacy in more lab animals. 要是一间实验室幸运到发现了能治愈实验室老鼠身上疾病的分子,下一个步骤是在更多的实验室动物上测试它的毒性和效用。
概述
PTCL患者口服5-氮杂胞苷和罗米地辛表现出明显的活性: 一项多中心I期研究
发表时间:2019-08-30
影响因子:16.6
作者: Owen O'Connor
期刊:Blood
The peripheral T-cell lymphoma (PTCL) are uniquely sensitive to epigenetic modifiers. Based on the synergism between histone deacetylase (HDAC) inhibitors and hypomethylating agents we established in preclinical PTCL models, we conducted a phase 1 study of oral 5-azacytidine (AZA) and romidepsin (ROMI) in patients with advanced lymphoid malignancies, with emphasis on PTCL. Following a 3+3 design patients were assigned to one of seven cohorts with AZA doses ranging from 100 mg daily on days 1-14 to 300 mg daily on days 1-21, ROMI doses ranging from 10 mg/m2 on days 8 and 15, to 14 mg/m2 on days 8, 15, and 22, and cycles of 21 to 35 days. Co-primary endpoints included maximum tolerated dose (MTD) and dose-limiting toxicity (DLT). We treated a total of 31 patients. The MTD was AZA 300 mg on days 1-14 and ROMI 14 mg/m2 on days 8, 15 and 22 on a 35-day cycle. DLTs included grade 4 thrombocytopenia, prolonged grade 3 thrombocytopenia, grade 4 neutropenia, and pleural effusion. There were no treatment-related deaths. The combination was substantially more active in patients with PTCL than non-T-cell lymphoma.
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