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fecal immunochemical test

肿瘤

关键词肿瘤 诊断方式 结肠癌

词汇介绍

拓展阅读

解析


Fecal   英 /'fiːkəl/   美 /'fikəl/

释    义   adj. 排泄物的;残渣的;糟粕的

例    句   Fecal Occult Blood test Every year to detect hidden blood in the stool, a possible sign of colon cancer. 粪便潜血检验每年一次,以检查粪便中是否潜血,粪便潜血是结肠癌的可能徵兆。

 

Immunochemical   英 /,ɪmjʊnəʊ'kemɪkəl/

释    义   adj. 免疫化学的

同根词   immune adj. 免疫的;免于……的,免除的

               immunized adj. 免疫的

               immunocompetent adj. 免疫活性的

               immunogenic adj. 产生免疫性的;

               immune n.免疫者;免除者

               immunity n. 免疫力;豁免权;免除

               immunization n. 免疫

               immunodeficiency n. [免疫] 免疫缺陷

               immunisation n. 免疫;免疫法

               immunoglobulin n. [免疫][生化] 免疫球蛋白;免疫血球素

               immunoassay n. 免疫分析,免疫测定

               immunochemistry n. 免疫化学

               immunocompetence n. 免疫能力;免疫活性

               immunoelectrophoresis n. [临床] 免疫电泳

               immunofluorescence n. [免疫] 免疫荧光;萤光免疫检验法

               immunogen n. [免疫] 免疫原

               immunogenicity n. [免疫] 免疫原性;致免疫性;致免疫力;

例    句   Conclusion: The condition of children with HLH can be effectively control early with immunochemical therapy of HLH-04 protocol. 结论:儿童HLH可通过采用HLH-04方案的免疫化学治疗,早期得以有效控制。

 

Test   英 /test/

释    义   n. 测验,考查;测试;检验;化验;v. 测验;化验,检查;试验,测试;考验

例    句   Why do we have to do durability test? 我们为什么要做耐久性测试?

概述

粪便免疫化学测试(FIT)是一种早期结肠癌筛查程序,能够准确的检测粪便中是否出血,而这通常是癌症的一个早期征象,如果检测结果为阴性,那么患者不再需要进行结肠镜检查。而且患者可以保留隐私,在家中采集样品。FIT结肠癌筛查参与者可以寄送粪便样本至检测中心,然后接收FIT筛查结果。粪便免疫化学试验,由美国预防服务工作组认可,在美国成为越来越普遍的大肠癌筛查方法。有研究结果显示,粪便免疫化学试验阳性后,与那些在一个月内即接受随访结肠镜检查的患者相比,等待10个多月后才接受结肠镜检查的患者结直肠癌(C

Effects of Oral Anticoagulants and Aspirin on Performance of Q1 Fecal Immunochemical Tests in Colorectal Cancer Screening复制标题

口服抗凝药和阿司匹林对Q1粪便免疫化学检测在结直肠癌筛查中的作用

发表时间:2019-05-01

影响因子:19.2

作者: Kristin Ranheim Randel

期刊:Gastroenterology

BACKGROUND AND AIMS: The fecal immunochemical test (FIT) is the tool most frequently used for colorectal cancer (CRC) screening worldwide. It is unclear how the use of aspirin and oral anticoagulants in the screening population affects the diagnostic performance of FIT. METHODS: We performed a cross-sectional study in an ongoing CRC screening trial in Norway. Participants aged 50-74 years with a positive result from an FIT (>15 μg hemoglobin/g feces) and subsequent colonoscopy (reference standard) were included. Those who used regular aspirin, warfarin, or direct-acting oral anticoagulants (DOACs) were defined as users. Non-users were matched according to age, sex, screening center, and screening round. The primary outcomes were the positive predictive value (PPV) for CRC and advanced adenoma.RESULTS: Among 4908 eligible participants, 1008 used aspirin, 147 used warfarin, 212 used DOACs, and 3541 were non-users. CRCs were found in 234 individuals and advanced adenomas in 1305 individuals. The PPV for CRC was 3.8% for aspirin users vs 6.4% for matched non-users (P = .006), The PPV for advanced adenoma in aspirin users was 27.2% vs 32.6% for matched non-users (P = .011). For DOAC, the PPV for CRC was 0.9% in users vs 6.8% in matched non-users (P = .001).

译文

背景与目的:粪便免疫化学测试(FIT)是全球范围内最常用于结肠直肠癌(CRC)筛查的工具。尚不清楚筛选人群中使用阿司匹林和口服抗凝剂如何影响FIT的诊断性能。方法:我们在挪威正在进行的CRC筛查试验中进行了一项横断面研究。包括年龄在50-74岁之间的FIT(> 15μg血红蛋白/ g粪便)和随后的结肠镜检查(参考标准)呈阳性结果的参与者。那些使用常规阿司匹林,华法林或直接作用口服抗凝剂(DOAC)的患者被定义为使用者。根据年龄,性别,筛查中心和筛查轮对非用户进行匹配。主要结局是CRC和晚期腺瘤的阳性预测值(PPV)。结果:在4908名合格参与者中,有1008名使用了阿司匹林,147名使用了华法林,212名使用了DOAC,以及3541名非使用者。在234个人中发现了CRC,在1305个人中发现了晚期腺瘤。阿司匹林使用者的CRC PPP为3.8%,相匹配的非使用者为6.4%(P = .006),阿司匹林使用者的晚期腺瘤的PPV为27.2%,相匹配的非使用者为32.6%(P = .011) 。对于DOAC,CRC的PPV在用户中为0.9%,在匹配的非用户中为6.8%(P = .001)。