肿瘤
词汇介绍
拓展阅读
解析
Maximum 英 /'mæksɪməm/ 美 /ˈmæksəməm/
释 义 n. [数] 极大,最大限度;最大量;adj. 最高的;最多的;最大极限的;复数 maximums或maxima
同根词 maximal adj. 最高的,最大的;最全面的;maximally adv. 最大地;最高地;maximization n. [数] 极大化,最大化;maximizing n. 最大化;达到极大值;
例 句 But you only get the maximum benefit if you implement all of them, because their power comes from their interaction. 但您只能在实现所有方法的情况下获得最大收益,因为它们的力量来自它们之间的交互。
Tolerated
释 义 v. 容忍;忍受(tolerate的过去分词);adj. 可接纳的
例句 Some thoughts on why this sort of thing is tolerated. 一些人的想法是,为什么这类事件被容忍。
Dose 英 /dəʊs/ 美 /dos/
释 义 n. 剂量;一剂,一服;vi. 服药;vt. 给药;给…服药;n. (Dose)人名;(德)多泽;(意、西、葡、塞)多塞;(英)多斯;过去式 dosed;过去分词 dosed;现在分词 dosing;第三人称单数 doses
同根词 dosage n. 剂量,用量;dosing n. 定量给料,配量;精密分注;dosimetry n. [临床] 剂量学;放射量测定
例 句 There is no other product like this on the market. Tasteless, one dose a day, easy, easy. 市场上没有其他的产品像这个产品一样。没有味道,每天一剂,方便,容易。
概述
Metronomic chemotherapy and nanocarrier platforms复制标题
节拍化疗和纳米载体平台
发表时间:2017-08-01
影响因子:6.5
作者: Amr S. Abu Lila
期刊:Cancer Lett.
Chen and colleagues have explored the potential use of a nanoparticulate delivery system that can actively target tumor vasculature in metronomic chemotherapy. For achieving active tumor vasculature targeting, the surface of poly(lactic-co-glycolic acid)-based nanoparticles was decorated with a specific ligand moiety, SP5.2 peptide, a ligand for VEGFR-1 highly expressed on tumor vascular ECs [78], [79]. The anti-angiogenic/antitumor efficacy of the prepared SP5.2 peptide-conjugated nanoparticles encapsulating the cytotoxic drug DTX (SP5.2 DTX-NP) was challenged against a breast cancer xenograft tumor model using either MTD or metronomic dosing. Results revealed that metronomic SP5.2-DTX-NP exhibited potent antitumor activity, mainly via the anti-angiogenic potential of DTX, which was selectively delivered into tumor vascular endothelial cells via the interaction of SP5.2 peptide with the over-expression of VEGFR-1 on tumor vessels. In addition, targeted metronomic chemotherapy induced superior antitumor activity with minimal drug-associated toxicity, compared with treatment given in a maximum tolerated dose (MTD) regimen [74]. Later, the same research group [10] investigated the efficacy of a metronomic PTX using a tumor-vasculature targeted nanocarrier, which consisted of F56-conjugated PTX-loaded nanoparticles (F56-PTX-NP) in a breast cancer xenograft tumor model. F56 is a peptide ligand with high binding avidity to the VEGFR-1 highly expressed on tumor vascular ECs.
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