肿瘤
词汇介绍
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解析
Peripheral 英 /pə'rɪf(ə)r(ə)l/ 美 /pə'rɪfərəl/
释 义 adj. 外围的；次要的；（神经）末梢区域的；n. 外部设备
同根词 peripherally adv. 周边地；外围地；次要地；periphery n. 外围，边缘；圆周；圆柱体表面
例 句 Objective:To study the application and significance of making chromosome specim peripheral blood lymphocyte(PBL) by large volume culture for students experiment. 目的: 探讨大体积培养人外周血淋巴细胞(PBL)染色体标本技术在学生实验中的应用及意义。
Lymphoma 英 /lɪm'fəʊmə/ 美 /lɪm'fomə/
释 义 n. [肿瘤] 淋巴瘤；复数 lymphomas或lymphomata
同根词 lymphatic adj. 淋巴的；含淋巴的；lymphocytic adj. 淋巴细胞的；淋巴球的；lymphatic n. 淋巴管；淋巴腺；lymphocytosis n. 淋巴球增多；淋巴球过多症；lymphopoiesis n. 淋巴组织生成；淋巴细胞增殖
例 句 No two people with leukemia, lymphoma or myeloma are alike, nor are any two relatives or friends of someone with one of these illnesses the same. 没有任何两个白血病、淋巴瘤或者骨髓瘤的患者是完全相同的，同样，他们的亲戚朋友也不会。
概述
复制标题PTCL患者口服5-氮杂胞苷和罗米地辛表现出明显的活性: 一项多中心I期研究
发表时间：2019-08-30
影响因子：16.6
作者： Owen A. O’Connor
期刊：Blood
The peripheral T-cell lymphoma (PTCL) are uniquely sensitive to epigenetic modifiers. Based on the synergism between histone deacetylase (HDAC) inhibitors and hypomethylating agents we established in preclinical PTCL models, we conducted a phase 1 study of oral 5-azacytidine (AZA) and romidepsin (ROMI) in patients with advanced lymphoid malignancies, with emphasis on PTCL. Following a 3 + 3 design patients were assigned to one of seven cohorts with AZA doses ranging from 100 mg daily on days 1-14 to 300 mg daily on days 1-21, ROMI doses ranging from 10 mg/m2 on days 8 and 15, to 14 mg/m2 on days 8, 15, and 22, and cycles of 21 to 35 days. Co-primary endpoints included maximum tolerated dose (MTD) and dose-limiting toxicity (DLT). We treated a total of 31 patients. The MTD was AZA 300 mg on days 1-14 and ROMI 14 mg/m2 on days 8, 15 and 22 on a 35-day cycle. DLTs included grade 4 thrombocytopenia, prolonged grade 3 thrombocytopenia, grade 4 neutropenia, and pleural effusion. There were no treatment-related deaths. The combination was substantially more active in patients with PTCL than non-T-cell lymphoma.
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