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Application of a 5 Marker Panel to the Routine Diagnosis of Peripheral T-Cell Lymphoma With T-Follicular Helper Phenotype.
5 标记板在具有 T 滤泡辅助表型的外周 T 细胞淋巴瘤常规诊断中的应用。

摘要

The 2017 World Health Organization update introduced a new category of nodal peripheral T-cell lymphoma with T-follicular helper phenotype (PTCL-TFH) defined by expression of at least 2 or 3 TFH markers. Our study assesses the utility of an immunohistochemical panel of 5 TFH markers (CD10, BCL6, PD-1, CXCL13, and ICOS) for identification of TFH phenotype in angioimmunoblastic T-cell lymphoma (AITL) and PTCL not otherwise specified (NOS). Immunohistochemical for the 5 markers was performed on 22 cases of AITL and 29 cases of PTCL-NOS. Cases were reviewed for morphologic features characteristic of AITL. All AITL cases showed expression of ≥2 TFH markers. This panel resulted in reclassification of 41% PTCL-NOS cases to PTCL-TFH. Positive percent agreement for the TFH phenotype is 97% for PD1, 94% for ICOS, 44% for CD10 and CXCL13, and 29% for BCL6. Negative percent agreement for TFH phenotype is 100% for CD10, BCL6, and CXCL13, 82% for ICOS and 71% for PD1. AITL cases were more likely than PTCL-TFH cases to contain expanded CD21-positive follicular dendritic cell meshworks, clear cell cytology and polymorphous inflammatory background; however, there was a significant (P

译文

2017 世界卫生组织更新引入了一种新的淋巴结外周 T 细胞淋巴瘤,其 T 滤泡辅助表型 (PTCL-TFH) 由至少 2 或 3 个 TFH 标记的表达定义。我们的研究评估了由 5 个 TFH 标记 (CD10 、 BCL6 、 PD-1 、 CXCL13 和 ICOS) 组成的免疫组织化学小组在血管免疫母细胞 T 细胞淋巴瘤 (AITL) 中鉴定 TFH 表型的效用。和 PTCL 没有另外指定 (NOS)。对 22 例 AITL 和 29 例 PTCL-NOS 进行了免疫组织化学检测。对病例进行了 AITL 形态学特征的回顾。所有 AITL 病例均显示 ≥ 2 TFH 标记表达。该小组导致将 41% 起 PTCL-NOS 案件改叙为 PTCL-TFH。TFH 表型的阳性一致性为 PD1 的 97%,ICOS 的 94%,CD10 和 CXCL13 的 44%,bcl6 的 29%。CD10 、 BCL6 和 CXCL13 的 TFH 表型的阴性一致性为 100%,ICOS 为 82%,pd1 为 71%。AITL 病例比 PTCL-TFH 病例更容易包含扩增的 CD21-positive 滤泡树突状细胞网、透明细胞遗传学和多形性炎症背景; 然而,有显著性 (P

peripheral T-cell lymphoma

肿瘤 淋巴瘤 疾病
概述  :  

外周T细胞淋巴瘤,简称PTCL,是一组高度异质性的淋巴细胞异常恶性增殖性疾病。在我国,PTCL的病例占非霍奇金淋巴瘤25%~30%,显著高于欧美国家的10%-15%。据2008年WHO造血与淋巴组织肿瘤的分类标准,PTCL共包含22个亚型。我国最常见的亚型为结外NK/T 细胞淋巴瘤(鼻型);PTCL-非特指型;T 淋巴母细胞性淋巴瘤/白血病等。这些都属于外周T细胞淋巴瘤的范畴,无论是查询治疗方法还是最新动态都归类在PTCL中。 临床特征PTCL常见的临床表现为全身淋巴结肿大和/或结

Peripheral   英 /pə'rɪf(ə)r(ə)l/   美 /pə'rɪfərəl/

释    义   adj. 外围的;次要的;(神经)末梢区域的;n. 外部设备

同根词   peripherally adv. 周边地;外围地;次要地;periphery n. 外围,边缘;圆周;圆柱体表面

例    句   Objective:To study the application and significance of making chromosome specim peripheral blood lymphocyte(PBL) by large volume culture for students experiment. 目的: 探讨大体积培养人外周血淋巴细胞(PBL)染色体标本技术在学生实验中的应用及意义。

 

Lymphoma   英 /lɪm'fəʊmə/   美 /lɪm'fomə/

释    义   n. [肿瘤] 淋巴瘤;复数 lymphomas或lymphomata

同根词   lymphatic adj. 淋巴的;含淋巴的;lymphocytic adj. 淋巴细胞的;淋巴球的;lymphatic n. 淋巴管;淋巴腺;lymphocytosis n. 淋巴球增多;淋巴球过多症;lymphopoiesis n. 淋巴组织生成;淋巴细胞增殖

例    句   No two people with leukemia, lymphoma or myeloma are alike, nor are any two relatives or friends of someone with one of these illnesses the same. 没有任何两个白血病、淋巴瘤或者骨髓瘤的患者是完全相同的,同样,他们的亲戚朋友也不会。

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