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首页 > 医学词汇大全 > complement dependent cytotoxicity
complement dependent cytotoxicity

肿瘤

关键词肿瘤 临床研究术语 靶细胞

词汇介绍

拓展阅读

解析

Complement   英 /'kɒmplɪm(ə)nt/   美 /ˈkɑmpləmənt/

释    义   n. 补语;余角; 补足物vt. 补足,补助; 复数 complements; 过去式 complemented; 过去分词 complemented; 现在分词 complementing; 第三人称单数 complements

例    句   You do not want to duplicate efforts, though you may come to complement them.

虽然您可能会为其做补充,您不会想去做重复的工作。

 

Dependent   美 /dɪ'pɛndənt/

释    义   adj. 依靠的;从属的;取决于…的;n. 依赖他人者;受赡养者;复数 dependents

同根词   dependable adj. 可靠的,可信赖的;可信任的;dependency n. 属国;从属;从属物;dependence n. 依赖;依靠;信任;信赖;dependant n. 家眷;侍从;食客(等于dependent);dependability n. 可靠性;可信任;dependance n. 依赖性(等于dependence);depend vi. 依赖,依靠;取决于;相信,信赖

例    句   It comes with realising the Oneness of all Life, and how dependent you are on each other.

它产生于对所有生命都是一体的,以及你们是如何彼此互相依赖的认识之中。

 

Cytotoxicity /,saitəutɔk'sisiti/

释    义   n. 细胞毒性

同根词   cytoplasmic adj. 细胞质的;cytotoxic adj. [细胞] 细胞毒素的;cytopathogenic adj. 致细胞病变的;cytoplastic adj. 胞体质的;细胞质的(等于cytoplasm);cytoplasm n. [细胞] 细胞质;cytosol n. [细胞] 胞液,细胞溶质;cytoskeleton n. [细胞] 细胞骨架,细胞支架;cytoplast n. 细胞质(等于cytoplasm);cytostome n. 细胞口;入口孔;cytotoxin n. [细胞] 细胞毒素

例    句   In addition , they do not display cytotoxicity in uninfected normal cells.

此外,她们在未受感染的正常细胞中不显示细胞毒性。

概述

补体依赖细胞毒性又叫补体介导的细胞毒性,是指带有特异抗原的靶细胞(如正常细胞、肿瘤细胞、病毒感染细胞)与相应抗体结合后,在补体的参与下,引起靶细胞膜损伤,导致细胞膜的通透性增加、细胞死亡。近年来国际上有关肿瘤的免疫逃逸问题成为肿瘤领域的研究热点,肿瘤细胞逃避免疫监视的分子机制非常复杂,有些机制尚需进一步探讨。补体系统的一个重要的生理功能时溶解外来的细胞,也包括肿瘤细胞。传统上认为体内存在着多种可溶性及膜结合性的补体调节蛋白,它们以特定的方式与不同的补体成分相互作用,使补体的激活和抑制处于精细

Mogamulizumab treatment elicits autoantibodies attacking the skin in patients with adult T cell leukemia-lymphoma复制标题

Mogamulizumab治疗引起自身抗体攻击成人T细胞白血病淋巴瘤患者的皮肤

发表时间:2019-07-15

影响因子:8.9

作者: Takashi Ishida

期刊:Clin. Cancer Res.

RESULTS: Autoantibodies recognizing human keratinocytes or melanocytes were found in the sera of 6 of 8 patients suffering from mogamulizumab-induced erythema multiforme. In one patient, complement-dependent cytotoxicity (CDC) mediated by autoantibodies against keratinocytes or melanocytes was proportionally related to the severity of the erythema multiforme. The presence of autoantibodies in the epidermis was confirmed in all biopsy specimens of mogamulizumab-induced erythema multiforme (n = 12). Furthermore, colocalization of autoantibodies and C1q, suggesting the activation of CDC, was observed in 67% (8/12). In contrast, no autoantibody or C1q was found in ATL tumor skin lesions (n = 13). Consistent with these findings, NGS demonstrated that IgM germline genes had newly emerged and expanded, resulting in IgM repertoire skewing at the time of erythema multiforme.CONCLUSIONS: Mogamulizumab elicits autoantibodies playing an important role in skin-related AEs, possibly associated with regulatory T-cell depletion. This is the first report demonstrating the presence of skin-directed autoantibodies after mogamulizumab treatment.

译文

结果:在患有莫加莫珠单抗诱导的多形性红斑的8例患者中,有6例的血清中发现了识别人角质形成细胞或黑素细胞的自身抗体。在一名患者中,由自身抗体介导的针对角质形成细胞或黑素细胞的补体依赖性细胞毒性(CDC)与多形红斑的严重程度成正比相关。在mogamulizumab诱导的多形红斑的所有活检标本中均证实了表皮中存在自身抗体(n = 12)。此外,在67%(8/12)中观察到自身抗体和C1q的共定位,表明CDC激活。相反,在ATL肿瘤皮肤病变中未发现自身抗体或C1q(n = 13)。与这些发现相一致的是,NGS证明了IgM种系基因是新出现并扩展的,从而导致IgM多形红斑时的组库偏斜。结论:莫加莫珠单抗引发自身抗体在与皮肤有关的AE中起重要作用,可能与调节性T细胞耗竭有关。这是第一份证明莫加单抗治疗后存在皮肤定向自身抗体的报告。