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cytoreductive surgery

肿瘤

关键词肿瘤 治疗方法 肿瘤切除

词汇介绍

拓展阅读

解析

Cytoreductive 

释    义   adj. 细胞减少性的

例    句   Methods:50 patients with mean platinum free interval (PFI) of 6.6 months (0.5~36 months) received secondary cytoreductive surgery followed by second line chemotherapy. 方法:50例平均停用铂类药物化疗时间(PFI)为6 .6(0 .5-36)个月的卵巢癌患者接受二次肿瘤细胞减灭术及术后二线化疗。

 

Surgery   英 /'sɜːdʒ(ə)rɪ/   美 /'sɝdʒəri/

释    义   n. 外科;外科手术;手术室;诊疗室;复数 surgeries

同根词   surgical adj. 外科的;手术上的;surgically adv. 如外科手术般地;surgeon n. 外科医生;surgical n. 外科手术;外科病房

例    句   However, they almost always respond to the combination of antibiotics and surgery. 然而,他们几乎总是对抗生素和外科手术的结合产生反应。

概述

最早的再次肿瘤细胞减灭术由Berek等于1980年提出,此后逐渐成为研究热点。肿瘤细胞减灭术是一种肿瘤治疗方法,肿瘤细胞减灭术就是减灭肿瘤细胞的数量,是指针对一些比较大的或者是会出现压迫症状,但是却无法将肿瘤完全切除的患者,通过将肿瘤部分切除来缓解症状并减轻肿瘤负担的手术。该方法并不适用于所有肿瘤,而是通常只适用于晚期卵巢癌并且盆腔中有大肿块和广泛移植趋势的患者。在卵巢癌患者中,肿瘤细胞减灭术是指对于晚期卵巢癌患者以最大限度地切除肿瘤为目的的手术措施,包括初次(primary cytored

Cytoreductive surgery for ovarian cancer: quality assessment复制标题

卵巢癌细胞减灭术的质量评价

发表时间:2017-11-01

影响因子:14.2

作者: A. H. Brand

期刊:Ann. Oncol.

Surgical cytoreduction of ovarian cancer was first described by Meigs, in his textbook, ‘Tumors of the Female Pelvic Organs’. Although it took many years for the use of cytoreductive surgery to become routine, the concept of surgical cytoreduction as an aid to adjuvant treatment, which initially was radiation therapy, was the fundamental basis of this strategy. Support for aggressive surgical cytoreduction gained momentum with the publication of Griffith’s seminal paper. Two publications by Hoskins et al., based on Gynaecologic Oncology Group (GOG) protocols, further supported the role of aggressive surgical cytoreduction and confirmed the inverse relationship between the amount of residual disease at primary surgery and optimal survival outcomes. Analysis of high-volume centers confirmed the importance of optimal tumor resection. Aided by the concurrent development and routine use of cisplatin and paclitaxel chemotherapy, the concept of aggressive surgical cytoreduction followed by cytotoxic chemotherapy has become the standard of care for ovarian cancer.

译文

Meigs在他的教科书“女性盆腔器官的肿瘤”中首次描述了卵巢癌的外科细胞减少术。尽管减细胞外科手术已花费很多年的常规时间,但手术减细胞的概念作为辅助治疗的辅助手段(最初是放射疗法)是该策略的基本基础。随着格里菲斯(Griffith)的开创性论文的发表,对积极的外科细胞减少的支持获得了动力。 Hoskins等人根据妇科肿瘤学小组(GOG)方案发表的两篇论文进一步支持了积极的外科细胞减灭术的作用,并证实了初次手术时残留疾病的数量与最佳生存结果之间存在反比关系。高容量中心的分析证实了最佳肿瘤切除的重要性。在顺铂和紫杉醇化疗的同时发展和常规使用的辅助下,积极的外科细胞减少术随后进行细胞毒性化学治疗的概念已成为卵巢癌的治疗标准。