释 义 adj. 双特异的
例 句 Objective: To study bidirectional binding ability and immunoactivity of anti-CD3/anti-glioma bispecific antibodies(BsAb), and to study its effect on T lymphocytes cells. 目的：鉴定自制的抗CD3-抗胶质瘤双特异性抗体（BsAb）的双向结合能力，测定其免疫活性及其对T淋巴细胞的作用。
Antibody 英 /'æntɪbɒdɪ/ 美 /'æntɪ'bɑdi/
释 义 n. [免疫] 抗体；复数 antibodies
例 句 Each antibody in this kit recognizes only its specific target and does not cross-react with other family members. 本试剂盒中的每个抗体只识别其特异靶标蛋白，不与其他家族成员交叉反应。
作者： Aran F. Labrijn
期刊：Nat Rev Drug Discov
The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from relatively small proteins, merely consisting of two linked antigen-binding fragments, to large immunoglobulin G (IgG)-like molecules with additional domains attached. An attractive bsAb feature is their potential for novel functionalities-that is, activities that do not exist in mixtures of the parental or reference antibodies. In these so-called obligate bsAbs, the physical linkage of the two binding specificities creates a dependency that can be temporal, with binding events occurring sequentially, or spatial, with binding events occurring simultaneously, such as in linking an effector to a target cell. To date, more than 20 different commercialized technology platforms are available for bsAb creation and development, 2 bsAbs are marketed and over 85 are in clinical development. Here, we review the current bsAb landscape from a mechanistic perspective, including a comprehensive overview of the pipeline.