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首页 > 医学词汇大全 > bispecific antibody
bispecific antibody

肿瘤

关键词肿瘤 临床研究术语 新型抗体

词汇介绍

拓展阅读

解析

Bispecific

释    义   adj. 双特异的

例    句   Objective: To study bidirectional binding ability and immunoactivity of anti-CD3/anti-glioma bispecific antibodies(BsAb), and to study its effect on T lymphocytes cells. 目的:鉴定自制的抗CD3-抗胶质瘤双特异性抗体(BsAb)的双向结合能力,测定其免疫活性及其对T淋巴细胞的作用。

 

Antibody   英 /'æntɪbɒdɪ/   美 /'æntɪ'bɑdi/

释    义   n. [免疫] 抗体;复数 antibodies

例    句   Each antibody in this kit recognizes only its specific target and does not cross-react with other family members. 本试剂盒中的每个抗体只识别其特异靶标蛋白,不与其他家族成员交叉反应。

概述

双特异性抗体(BsAb)是指具有两个不同的抗原结合部位,能有效介导效应物和靶分子结合的新型抗体。在自然状态下不存在双特异性抗体,只能通过人工制备。双特异性抗体能够起到特殊的生物学功能,如(1)免疫细胞的招募和激活,通过同时靶向肿瘤和免疫细胞达到召集免疫细胞清除肿瘤细胞的目的;(2)受体共刺激或抑制,利用BsAb拮抗2种或多种信号传导配体,避免逃逸机制从而改善治疗效果;(3)促进蛋白复合物形成;(4)多价病毒中和等方式等。目前BsAb的临床开发主要集中于癌症和炎性疾病,主要作用机制是同时干涉病

Bispecific antibodies: a mechanistic review of the pipeline复制标题

双特异性抗体: 管道的机制综述

发表时间:2019-06-07

影响因子:57.6

作者: Aran F. Labrijn

期刊:Nat Rev Drug Discov

The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from relatively small proteins, merely consisting of two linked antigen-binding fragments, to large immunoglobulin G (IgG)-like molecules with additional domains attached. An attractive bsAb feature is their potential for novel functionalities-that is, activities that do not exist in mixtures of the parental or reference antibodies. In these so-called obligate bsAbs, the physical linkage of the two binding specificities creates a dependency that can be temporal, with binding events occurring sequentially, or spatial, with binding events occurring simultaneously, such as in linking an effector to a target cell. To date, more than 20 different commercialized technology platforms are available for bsAb creation and development, 2 bsAbs are marketed and over 85 are in clinical development. Here, we review the current bsAb landscape from a mechanistic perspective, including a comprehensive overview of the pipeline.

译文

术语双特异性抗体(bsAb)用于描述旨在识别两种不同表位或抗原的分子大家族。 BsAb的形式多种多样,从相对较小的蛋白质(仅由两个连接的抗原结合片段组成),到带有附加结构域的大型免疫球蛋白G(IgG)样分子。有吸引力的bsAb功能是其潜在的新功能-即亲本或参考抗体混合物中不存在的活性。在这些所谓的专一性bsAb中,两种结合特异性的物理联系产生了一种依赖性,这种依赖性可以是暂时的,结合事件顺序发生,或者是空间的,结合事件同时发生,例如将效应子连接至靶细胞。迄今为止,已有20多种不同的商业化技术平台可用于bsAb的创建和开发,有2种bsAb已上市,并且有超过85种正在进行临床开发。在这里,我们从机械的角度回顾了当前的bsAb格局,包括对管线的全面概述。