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Does metronomic chemotherapy induce tumor angiogenic dormancy? A review of available preclinical and clinical data.
节拍化疗诱导肿瘤血管生成休眠吗?现有临床前和临床数据的综述。
Angiogenic switch Circulating endothelial progenitor Low dose chemotherapy Thrombospondin-1 Vascular endothelial growth factor
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摘要

Tumor dormancy is the ability of cancer cells to survive in a non-proliferating state. This condition can depend on three main mechanisms: cell cycle arrest (quiescence or cell dormancy), immunosurveillance (immunologic dormancy), or lack of functional blood vessels (angiogenic dormancy). In particular, under angiogenic dormancy, cancer cell proliferation is counterbalanced by apoptosis owing to poor vascularization, impeding tumor mass expansion beyond a microscopic size, with an asymptomatic and non-metastatic state. Tumor vasculogenic or non-angiogenic switch is essential to promote escape from tumor dormancy, leading to tumor mass proliferation and metastasis. In avascular lesions angiogenesis process results blocked from the equilibrium between pro- and anti-angiogenic factors, such as vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1), respectively. The angiogenic switch mainly depends on the disruption of this balance, in favor of pro-angiogenic factors, and on the recruitment of circulating endothelial progenitors (CEPs) that promote the formation of new blood vessels. Metronomic chemotherapy, the regular intake of doses able to sustain low but active concentrations of chemotherapeutic drugs during protracted time periods, is an encouraging therapeutic approach that has shown to upregulate anti-angiogenic factors such as TSP-1 and decline pro-angiogenic factors such as VEGF, suppressing the proangiogenic cells such as CEPs. In this perspective, metronomic chemotherapy may be one of the available therapeutic approaches capable to modulate favorably the angiogenic tumor dormancy, but further research is essential to better define this particular characteristic.

译文

肿瘤休眠是癌细胞在非增殖状态下生存的能力。这种情况取决于三个主要机制: 细胞周期阻滞 (静止或细胞休眠) 、免疫监视 (免疫休眠) 或缺乏功能性血管 (血管生成休眠)。特别是,在血管生成休眠状态下,由于不良的血管化,癌细胞增殖被细胞凋亡抵消,阻碍肿瘤肿块扩张超过微观尺寸,处于无症状和非转移状态。肿瘤血管生成或非血管生成开关对于促进摆脱肿瘤休眠,导致肿瘤大量增殖和转移至关重要。在无血管病变中,血管生成过程导致促血管生成因子和抗血管生成因子之间的平衡受阻,如血管内皮生长因子 (VEGF) 和 thrombospondin-1 (TSP-1)。血管生成开关主要取决于这种平衡的破坏,有利于促血管生成因子,以及促进新血管形成的循环内皮祖细胞 (CEPs) 的募集。节拍化疗,能够在长时间内维持低但有效的化疗药物浓度的定期剂量摄入, 是一种令人鼓舞的治疗方法,已显示上调抗血管生成因子如 TSP-1,并降低促血管生成因子如 VEGF,抑制促血管生成细胞如 CEPs。从这个角度来看,节拍化疗可能是一种有效的治疗方法,能够有利地调节血管生成肿瘤的休眠,但是进一步的研究对于更好地定义这一特定特征是必要的。

metronomic chemotherapy

肿瘤 化疗 治疗方法
概述  :  

2000年,Folkman及其同事通过动物移植瘤模型发现持续应用小剂量环磷酰胺能够使肿瘤血管床的内皮细胞持续凋亡。同年,Kerbel也证实持续低剂量的长春花碱能够抑制肿瘤血管生成,使移植瘤缩小。在这两项开创性研究的基础上,Hanahan提出了节拍化疗的概念。节拍化疗是近年来兴起的一种新的治疗模式,通过相对低剂量、频繁的应用细胞毒性药物,使药物能够长时间维持在相对较低、但仍有抗肿瘤活性的血药浓度,并减轻药物毒副作用。 优势传统化疗模式采取周期性(多数为3周)的给药方式杀肿瘤。在化疗过

Metronomic   /,mɛtrə'nɑmɪk/

释    义   adj. 节拍器的;有节奏的

例    句   Objective: To explore the role of metronomic therapy on treatment of advanced primary hepatocarcinoma .  目的:探索节拍疗法在晚期原发性肝癌治疗中的作用。

 

Chemotherapy   英 /,kiːmə(ʊ)'θerəpɪ; ,kem-/   美 /,kimo'θɛrəpi/

释    义   n. [临床] 化学疗法

同根词   chemotherapeutic adj. 化学疗法的;chemistry n. 化学;化学过程;chemist n. 化学家;药剂师;chemiluminescence n. [化学] 化学发光,化合光;chemisorption n. [化学] 化学吸收作用;chemoreceptor n. 化学受体;[生理] 化学感受器(等于chemoceptor);chemosynthesis n. [化学] 化学合成;chemisorb vt. 用化学方法吸收;用化学方法吸附

例    句   If any cancer remains in the abdomen or chest after chemotherapy, it can be treated with an operation to remove your lymph glands . 如果任何癌症在化疗后仍然存在于腹部或胸部,可以通过手术切除淋巴结来治疗。

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