释 义 n. 脱氢皮质醇，泼尼松龙（一种糖皮质激素）
例 句 The combination of prednisolone and azathioprine has only a minor effect, whereas the addition of ciclosporin attenuates protective antibody responses to influenza vaccination. 泼尼松龙和硫唑嘌呤联合应用的影响较小，而加用环孢素则减弱了针对流行性感冒接种的保护性抗体应答。
作者： Nicholas J A Webb
The best initial prednisolone regimen for children presenting with steroid sensitive nephrotic syndrome remains unknown. The eight week course first described in the 1960s by the International Study of Kidney Disease in Children (prednisolone 60 mg/m2 for four weeks then 40 mg/m2 on alternate days for four weeks) continues to be used in most UK centres and in many other countries. However, systematic review data suggest that a more intensive initial treatment course improves clinical outcomes. When the prednisolone in nephrotic syndrome (PREDNOS) trial started, six randomised controlled trials had compared the eight week course with a range of different prednisolone regimens of three months or longer. A 2005 Cochrane review concluded that prednisolone treatment of three months or longer statistically significantly reduced the rate of relapse at 12-24 months and the rate of frequently relapsing nephrotic syndrome. The Kidney Disease: Improving Global Outcomes guidelines published in 2012 supported the conclusions of this Cochrane review. These guidelines recommended daily prednisolone treatment of 60 mg/m2 or 2 mg/kg for four to six weeks followed by 40 mg/m2 or 1.5 mg/kg on alternate days and continued for two to five months, with tapering of the dose.