首页 > 医学词汇大全 > regulatory T cells
regulatory T cells

肿瘤

关键词肿瘤 临床研究术语 Tregs

词汇介绍

拓展阅读

解析

Regulatory   /ˈrɛɡjʊˌleɪtɔri/

释    义   adj. 管理的;控制的;调整的

同根词   regulation adj. 规定的;平常的;regulative adj. 调整的,调节的;管制的;regulation n. 管理;规则;校准;regulator n. 调整者;校准器;regularization n. 规则化;调整;合法化;

例    句   Perhaps the best reason for regulators to be suspicious about innovation is that so much of it in the modern world is aimed at facilitating regulatory and tax arbitrage. 监管者之所以对创新怀有疑虑,最关键的原因可能在于,现代社会中太多创新的目的都是为监管和税收套利提供便利。

 

Cells 

释    义   n. [细胞] 细胞;单元格(cell的复数);牢房;小屋;v. 住在牢房中(cell的三单形式)

例    句   If you try to shift cells up and down, then when you unhide the hidden cells, where should everything shift? 如果您尝试改变单元格的向上和向下,然后当你打开隐藏的单元格,所有内容应该在哪里移动?

概述

名为Tregs(The regulatory T cells)的调节性T细胞是种天然存在的T细胞亚群,它们能够负向调节机体免疫反应,通过诱导和维持对自身抗原的耐受性来维持体内免疫平衡。在健康人体内,Tregs能抑制过度的免疫反应,从而预防自身免疫性疾病。但另一方面,它们也可能会限制免疫系统对抗癌症的能力,让肿瘤细胞逃避免疫监视。 分类调节性T细胞可以分为天然产生的自然调节性T细胞,主要是CD4+CD25+Treg;诱导产生的适应性调节性T细胞,它是小剂量抗原或免疫抑制性细胞因子诱导

Using immuno-PET imaging to monitor kinetics of T cell-mediated inflammation and treatment efficiency in a humanized mouse model for GvHD复制标题

使用免疫PET成像监测T细胞介导的炎症动力学和人源化GvHD小鼠模型的治疗效率

发表时间:2019-08-31

影响因子:7.2

作者: Stefanie Pektor

期刊:Eur. J. Nucl. Med. Mol. Imaging

Since donor T cells are the disease-mediating immune cells, we imaged T cell distribution in a clinical relevant GvHD model using immunodeficient mice that were engrafted with a human immune system. By Zr-labeled anti-human CD3 mAb and PET/MRI, we show fast and massive infiltration of T cells into the spleen and liver of humanized mice. We were able to show that distribution and proliferation of T cells in vivo could not only be visualized by immuno-PET/MRI but furthermore strongly correlated with clinical symptoms of GvHD. The most affected organ in the early phase of GvHD development was the liver with enormous T cell infiltration in distinct areas. In particular, the pattern of tracer accumulation within the liver with a spot-like periportal accumulation reflects early signs of GvHD that cannot be captured by other noninvasive methods. Transfer of Treg significantly suppressed T cell proliferation and thus prevented GvHD-associated clinical symptoms such as hepatitis. Immuno-PET/MRI data revealed a marked reduction in T cell infiltration in the liver as well as GIT.

译文

由于供体T细胞是介导疾病的免疫细胞,我们使用植入人免疫系统的免疫缺陷小鼠在临床相关GvHD模型中成像T细胞。通过Zr标记的抗人CD3mAb和PET / MRI,我们显示T细胞快速和大量浸润到人源化小鼠的脾脏和肝脏中。我们能够证明体内T细胞的分布和增殖不仅可以通过免疫PET / MRI显现,而且还与GvHD的临床症状密切相关。在GvHD发育早期阶段受影响最大的器官是肝脏,在不同区域有巨大的T细胞浸润。特别地,具有斑点状门静脉积聚的肝脏内示踪剂积累的模式反映了GvHD的早期征兆,其不能通过其他非侵入性方法捕获。 Treg的转移显着抑制T细胞增殖,从而预防GvHD相关的临床症状,例如肝炎。免疫PET / MRI数据显示肝脏和GIT中T细胞浸润明显减少。