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首页 > 医学词汇大全 > allogeneic stem cell transplantation
allogeneic stem cell transplantation

肿瘤

关键词肿瘤 治疗方法 干细胞移植

词汇介绍

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解析

Allogeneic   英 /,ælə(ʊ)dʒɪ'niːɪk; -dʒɪ'neɪɪk/   美 /,ælədʒɪ'niɪk/

       adj. 同种异体的;同种异系的

同根词   allogamous adj. [植] 异体受精的;[植] 异花受粉的;allogamy n. 异体受精,异花受粉;allograft n. [病理] 同种异体移植物

       Conclusions: Percutaneous injection of autologous bone marrow and allogeneic bone powder appears to be an effective and simple method for unicameral bone cysts. 结论:经皮注射自体骨髓加异体骨粉移植治疗单房性骨囊肿是一种简单、微创、疗效确切的方法。

 

Stem   英 /stem/  美 /stɛm/

       n. 干;茎;船首;血统;vt. 阻止;除去…的茎;给…装柄;vi. 阻止;起源于某事物;逆行

同根词   stemmed adj. 去掉茎或梗的;有茎或梗的;装有…柄的;stemless adj. 无茎的;无梗的;stemmer n. 抽梗机,除梗器;抽梗工人;stemmed v. 起源于(stem的过去分词形式);除去…的茎;给(假花等)装梗

       But the flow from the stem tip prevents them from doing this. 但是,来自主干顶端的(激素)流会阻止它们这么做。

 

Transplantation   英 /,trænsplɑːn'teɪʃən/

       n. 移植;迁移;移民

同根词   transplantable adj. 可移植的,可移种的;transplant n. 移植;移植器官;被移植物;移居者;transplanter n. 移植机;移植者;transplant vi. 移植;迁移;移居;transplant vt. 移植;迁移;使移居

       This involves transplantation of the organ from one person to another person, often to replace a non-functional organ in the latter. 它包括从一个个体到另一个个体的器官移植,往往是为了取代后者失去功能的某个器官。

概述

干细胞移植是指在淋巴瘤、某些睾丸癌以及其他疾病治疗期间,医生使用健康的新的干细胞替代病态或无效的干细胞,或使用高剂量的一种治疗方法。需要移植的患者大体有以下几种原因:体内自身不能产生体内所需要的血细胞,因为其骨髓或血细胞呈现出一种病态且需要代替,或因为患者本身就有疾病,并接受了高剂量的化疗和/或放疗,与此同时破坏了癌细胞和干细胞。最常见的两种干细胞移植类型分别为自体移植和异基因移植。这两种干细胞移植是各类癌症治疗中比较常见的治疗方案,例如白血病、淋巴瘤和多发性骨髓瘤。异基因干细胞移植(All

Haploidentical vs. unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia in first complete remission: on behalf of the ALWP of the EBMT复制标题

半相合与无关异基因干细胞移植治疗首次完全缓解的急性淋巴细胞白血病: 代表EBMT的ALWP

发表时间:2019-08-19

影响因子:9.9

作者: Noga Shem-Tov

期刊:Leukemia

Unmanipulated haploidentical allogeneic stem cell transplantation (Allo-SCT) has become an attractive alternative for patients lacking HLA-matched sibling or unrelated donors. However, data of outcome in ALL is still scarce. The outcomes of 1234 adult patients with ALL in first complete remission (CR1) who underwent Allo-SCT between 2007 and 2016 were analyzed. Comparison was done between haploidentical donor (Haplo) (136 patients), matched unrelated donor (MUD 10/10) (809 patients), and mismatched unrelated donor (MMUD 9/10) (289 patients). Univariate analysis showed similar outcomes in Haplo, MUD, and MMUD, including OS, LFS, RI, NRM, AGVHD, and CGVHD. In multivariate analysis, Haplo was not associated with worse outcomes compared to MUD 10/10 and MMUD 9/10. Indeed, compared to Haplo, the hazard ratio (HR) for LFS, OS, RI, NRM, AGVHD, and CGVHD were 1.1 (p = 0.7), 0.9 (p = 0.4), 1.35 (p = 0.2), 0.7 (p = 0.2), 1.1 (p = 0.8), and 0.8 (p = 0.2) for MUD, respectively, and 1.1 (p = 0.8), 1.0 (p = 1.0), 1.2 (p = 0.3), 0.8 (p = 0.4), 1.2 (p = 0.3), and 0.9 (p = 0.6) for MMUD, respectively.

译文

未经处理的半相合同种异体干细胞移植(Allo-SCT)已成为缺乏HLA匹配的同胞或无关供体的患者的有吸引力的替代方案。然而,ALL的结果数据仍然很少。分析了2007年至2016年间接受Allo-SCT治疗的1234例ALL患者首次完全缓解(CR1)的结果。在haploidentical供体(Haplo)(136名患者),匹配的无关供体(MUD 10/10)(809名患者)和不匹配的无关供体(MMUD 9/10)(289名患者)之间进行比较。单变量分析显示Haplo,MUD和MMUD具有相似的结果,包括OS,LFS,RI,NRM,AGVHD和CGVHD。在多变量分析中,与MUD 10/10和MMUD 9/10相比,Haplo与较差的结果无关。实际上,与Haplo相比,LFS,OS,RI,NRM,AGVHD和CGVHD的危险比(HR)分别为1.1(p = 0.7),0.9(p = 0.4),1.35(p = 0.2),0.7(p) MUD分别为= 0.2),1.1(p = 0.8)和0.8(p = 0.2),1.1(p = 0.8),1.0(p = 1.0),1.2(p = 0.3),0.8(p = 0.4)对于MMUD,分别为1.2,(p = 0.3)和0.9(p = 0.6)。