摘要

Introduction of new myeloma therapies offers new options for patients refractory to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). In this multicenter study, patients with relapsed multiple myeloma, who have received at least three prior lines of therapy, are refractory to both an IMiD (lenalidomide or pomalidomide) and a PI (bortezomib or carfilzomib), and have been exposed to an alkylating agent were identified. The time patients met the above criteria was defined as time zero (T0). Five hundred and forty-three patients diagnosed between 2006 and 2014 were enrolled in this study. Median age at T0 was 62 years (range 31-87); 61% were males. The median duration between diagnosis and T0 was 3.1 years. The median number of lines of therapy before T0 was 4 (range 3-13). The median overall survival (OS) from T0 for the entire cohort was 13 (95% confidence interval (CI) 11, 15) months. At least one regimen recorded after T0 in 462 (85%) patients, with a median (95% CI) progression-free survival and OS from T0 of 5 (4, 6), and 15.2 (13, 17) months, respectively. The study provides the expected outcome of relapsed multiple myeloma that is refractory to a PI and an IMiD, a benchmark for comparison of new therapies being evaluated.

译文

新的多发性硬化症疗法的引入为免疫调节药物 (IMiDs) 和蛋白酶体抑制剂 (PIs) 难治的患者提供了新的选择。在这项多中心研究中,已经接受过至少三条治疗路线的复发性多发性骨髓瘤患者,对 IMiD (来那度胺或波那度胺) 都是难治的。和 PI (硼替佐米或卡非佐米),并且已经暴露于烷化剂中。患者达到上述标准的时间定义为时间 0 (T0)。543 至 2006年间诊断的 2014 名患者被纳入本研究。T0 的平均年龄为 62 岁 (范围为 31-87); 61% 是男性。诊断和 T0 之间的中位时间为 3.1 年。T0 治疗前的中位数为 4 (范围 3-13)。整个队列 T0 的中位总生存期 (OS) 为 13 (95% 置信区间 (CI) 11,15) 个月。在 462 (85%) 患者中,T0 后至少记录了一个方案,中位 (95% CI) 无进展生存期和 OS 从 T0 为 5 (4,6), 和 15.2 (13,17) 个月,分别。该研究提供了复发多发性骨髓瘤的预期结果,该病对 PI 和 IMiD 难治,IMiD 是正在评估的新疗法比较的基准。

immunomodulatory drugs

肿瘤 免疫 临床研究术语
概述  :  

免疫调节剂是具有调节机体免疫功能的药物,可以用于治疗免疫功能低下和/或紊乱所引起的疾病。这说明免疫调节剂具有药物的特性,并对机体免疫功能具有增强或抑制以及双向调节作用。免疫调节剂也包含生物反应修饰剂的概念,生物反应修饰剂是指某种可调节宿主免疫系统并与之相互作用的物质,可用于治疗如幼年型特发性关节炎、银屑病性关节炎等,这类制剂往往与免疫抑制剂共用,如甲氨蝶呤和皮质类固醇。 免疫调节剂的分类按照作用分类,根据免疫调节剂对机体免疫作用的不同,可以分为免疫增强剂、免疫抑制剂、双向免疫调节剂

Immunomodulatory 

       n. 免疫调节

       The result showed that bovine placenta has immunomodulatory enhancing function in the body, improving the power of body and health enhancing effect. 结果表明,牛胎盘有增强体内免疫调节功能、提高体力和促进健康的效果。

 

Drugs   美 /drʌgz/

       n. 毒品,[药] 药物

       "These drugs are not approved for this use, but they are frequently used, " she says. “这些药物的这种用途没有被批准,但是它们经常被使用,”她说。

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