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immunomodulatory drugs

肿瘤

关键词肿瘤 临床研究术语 免疫

词汇介绍

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解析

Immunomodulatory 

       n. 免疫调节

       The result showed that bovine placenta has immunomodulatory enhancing function in the body, improving the power of body and health enhancing effect. 结果表明,牛胎盘有增强体内免疫调节功能、提高体力和促进健康的效果。

 

Drugs   美 /drʌgz/

       n. 毒品,[药] 药物

       "These drugs are not approved for this use, but they are frequently used, " she says. “这些药物的这种用途没有被批准,但是它们经常被使用,”她说。

概述

免疫调节剂是具有调节机体免疫功能的药物,可以用于治疗免疫功能低下和/或紊乱所引起的疾病。这说明免疫调节剂具有药物的特性,并对机体免疫功能具有增强或抑制以及双向调节作用。免疫调节剂也包含生物反应修饰剂的概念,生物反应修饰剂是指某种可调节宿主免疫系统并与之相互作用的物质,可用于治疗如幼年型特发性关节炎、银屑病性关节炎等,这类制剂往往与免疫抑制剂共用,如甲氨蝶呤和皮质类固醇。 免疫调节剂的分类按照作用分类,根据免疫调节剂对机体免疫作用的不同,可以分为免疫增强剂、免疫抑制剂、双向免疫调节剂

Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition复制标题

免疫微环境调节掩盖了放疗和检查点抑制的治疗益处

发表时间:2019-08-13

影响因子:8.7

作者: Jared M. Newton

期刊:J Immunother Cancer

Background: Immune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have shown impressive clinical efficacy, however, most patients do not achieve durable responses. One major therapeutic obstacle is the immunosuppressive tumor immune microenvironment (TIME). Thus, we hypothesized that a strategy combining tumor-directed radiation with TIME immunomodulation could improve ICI response rates in established solid tumors.Methods: Using a syngeneic mouse model of human papillomavirus (HPV)-associated head and neck cancer, mEER, we developed a maximally effective regimen combining PD-1 and CTLA-4 inhibition, tumor-directed radiation, and two existing immunomodulatory drugs: cyclophosphamide (CTX) and a small-molecule inducible nitric oxide synthase (iNOS) inhibitor, L-n6-(1-iminoethyl)-lysine (L-NIL). We compared the effects of the various combinations of this regimen on tumor growth, overall survival, establishment of immunologic memory, and immunologic changes with flow cytometry and quantitative multiplex immunofluorescence.

译文

背景:实体瘤的免疫检查点抑制剂(ICIs),包括那些靶向程序性细胞死亡1(PD-1)和细胞毒性T淋巴细胞相关抗原4(CTLA-4),已经显示出令人印象深刻的临床疗效,但是,大多数患者没有实现持久的反应。一个主要的治疗障碍是免疫抑制性肿瘤免疫微环境(TIME)。因此,我们假设将肿瘤定向放射与TIME免疫调节相结合的策略可以改善已建立的实体瘤中的ICI应答率。方法:使用人乳头瘤病毒(HPV)相关头颈癌的同系小鼠模型mEER,我们开发了一种最有效的方案,结合PD-1和CTLA-4抑制,肿瘤定向放射和两种现有的免疫调节药物:环磷酰胺(CTX)和小分子诱导型一氧化氮合酶(iNOS)抑制剂,L-n6-(1-亚氨基乙基) - 赖氨酸(L-NIL)。我们用流式细胞术和定量多重免疫荧光比较了该方案的各种组合对肿瘤生长,总体存活,免疫记忆建立和免疫学变化的影响。