释 义 n. 免疫调节
例 句 The result showed that bovine placenta has immunomodulatory enhancing function in the body, improving the power of body and health enhancing effect. 结果表明，牛胎盘有增强体内免疫调节功能、提高体力和促进健康的效果。
Drugs 美 /drʌgz/
释 义 n. 毒品，[药] 药物
例 句 "These drugs are not approved for this use, but they are frequently used, " she says. “这些药物的这种用途没有被批准，但是它们经常被使用，”她说。
作者： Jared M. Newton
期刊：J Immunother Cancer
Background: Immune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have shown impressive clinical efficacy, however, most patients do not achieve durable responses. One major therapeutic obstacle is the immunosuppressive tumor immune microenvironment (TIME). Thus, we hypothesized that a strategy combining tumor-directed radiation with TIME immunomodulation could improve ICI response rates in established solid tumors.Methods: Using a syngeneic mouse model of human papillomavirus (HPV)-associated head and neck cancer, mEER, we developed a maximally effective regimen combining PD-1 and CTLA-4 inhibition, tumor-directed radiation, and two existing immunomodulatory drugs: cyclophosphamide (CTX) and a small-molecule inducible nitric oxide synthase (iNOS) inhibitor, L-n6-(1-iminoethyl)-lysine (L-NIL). We compared the effects of the various combinations of this regimen on tumor growth, overall survival, establishment of immunologic memory, and immunologic changes with flow cytometry and quantitative multiplex immunofluorescence.