摘要

Most studies have focused on CTC detection and counting in peripheral blood samples obtained by puncture of the median cubital vein. Fewer reports have tested the hypothesis that the chances of capturing and detecting CTCs might be higher in vessels closer to the tumor, especially in the main veins that drain blood from the organ invaded by the cancer. In this review, we will discuss studies that compared CTC yields in peripheral blood and in blood from vessels in the vicinity of the primary tumor (NSCLC, CCR, HCC and PDAC). As blood sampling in the main vessels close to the tumors is feasible in the early management of cancer or during surgery, we focused on the diagnostic and prognostic values of this approach and considered the possible added value of the “close to the tumor liquid biopsy”.

译文

大多数研究都集中在通过穿刺正中肘静脉获得的外周血样品中的CTC检测和计数。 更少的报告测试了这样的假设,即在靠近肿瘤的血管中捕获和检测CTC的机会可能更高,尤其是在从癌症侵入的器官中排出血液的主静脉中。 在这篇综述中,我们将讨论比较外周血和原发肿瘤附近血管(NSCLC,CCR,HCC和PDAC)血液中CTC产量的研究。 由于接近肿瘤的主要血管中的血液采样在癌症的早期治疗或手术期间是可行的,因此我们关注该方法的诊断和预后价值并考虑“接近肿瘤液体活检”的可能附加值。

liquid biopsy

肿瘤 肿瘤诊断 诊断方式
概述  :  

广义液体活检的概念是指,利用人体体液作为样本来源检测获取相关疾病信息的技术,这些体液样本主要包括血液、尿液、唾液甚至脑脊液。NIPT技术是指,通过对母体外周血中游离胎儿DNA的检测获取胎儿患病等信息的技术,这也可包含入广义的液体活检。但我们通常所说的液体活检一般是指通过检测这些体液样本中的循坏肿瘤细胞(CTC,circulating tumor cells)、循环肿瘤DNA(ctDNA,circulating tumor DNA)、游离DNA(cfDNA, circulating free

liquid   英  ['lɪkwɪd]   美  ['lɪkwɪd]

       adj. 液体的;清澈的;明亮的;易变的

               n. 液体,流体;流音

同词根   n.liquor 酒,含酒精饮料;溶液;液体;烈酒

       We started with all gas, no liquid.  我们从纯气态开始,没有液体。

 

biopsy   英  ['baɪɒpsɪ]   美  ['baɪɑpsi]

       n. 活组织检查;活组织切片检查;切片检查法

       I was not able to do this after having my biopsy done.  活组织切片检查后,我无法做法到这一点。

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