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首页 > 医学词汇大全 > dysplasia
dysplasia

肿瘤

关键词肿瘤 临床研究术语 癌前病变

词汇介绍

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解析

Dysplasia   英 /dɪs'pleɪzɪə/

释    义   n. 发育不良;发育异常;异常结构;异型增生;不典型增生

例    句   Objective: To investigate the relationship between gonad dysplasia and abnormal chromosome karyotypes. 研究目的:研究性腺发育异常与染色体异常的相关性。

概述

异型增生,又称为非典型增生或不典型增生,有的称之为间变。异型增生是一种以细胞学和机构异常为特征的癌前病变。细胞学异常包括细胞核增大、不规则、核仁明显、核浆比例增大、核分裂象增多;结构异常包括细胞排列紊乱、极向消失。依据细胞学和结构异常的程度通常可分为轻度、中度和重度异型增生。 胃粘膜上皮异型增生以胃为例,胃黏膜上皮异型增生和腺瘤由异型增生上皮构成。有学者提出,当异型增生上皮形成扁平病变,应用术语胃上皮异型增生(gastricepithelial dysplasia);当异型增生上皮

Association Between Indefinite Dysplasia and Advanced Neoplasia in Patients With Inflammatory Bowel Diseases Undergoing Surveillance复制标题

接受监测的炎症性肠病患者中不稳定发育与晚期肿瘤的相关性

发表时间:2019-08-12

影响因子:8.0

作者: Remi Mahmoud

期刊:Clin. Gastroenterol. Hepatol

We conducted a retrospective cohort analysis of patients with IBD undergoing colonoscopic surveillance between January 2001-December 2017 at a tertiary IBD referral center (The Mount Sinai Hospital (MSH), New York, NY, United States of America). Eligible patients were identified as described previously. Inclusion criteria were: an endoscopically and histologically confirmed diagnosis of IBD (Crohn’s disease [CD], ulcerative colitis [UC] or IBD-unclassified [IBD-U]); at least left-sided colonic involvement (UC patients, Montreal classification E2 or E3) or >30% involvement of colonic mucosa (CD, IBD-U); disease duration of > 8 years, or any disease extent or duration in patients with concomitant PSC; an “index” surveillance  colonoscopy (defined below) that was followed at least 3 months later by a procedure that allowed for colonic histologic assessment (i.e. at least one subsequent surveillance colonoscopy or colectomy specimen, or any type of procedure yielding a diagnosis of IND or CRN) and; histology analyzed by specialized IBD pathologists at MSH. Patients were excluded if ACRN or colectomy occurred prior to or within 3 months of the index colonoscopy. Patients with a history of IND or LGD prior to the index colonoscopy (henceforth referred to as “prior dysplasia”) were not excluded.

译文

我们对2001年1月至2017年12月期间在IBD三级转诊中心(美国纽约州纽约的西奈山医院(MSH))进行结肠镜监测的IBD患者进行了回顾性队列分析。如前所述鉴定合格的患者。纳入标准为:内镜和组织学证实的IBD诊断(克罗恩病[CD],溃疡性结肠炎[UC]或IBD-未分类[IBD-U]);至少左侧结肠受累(UC患者,蒙特利尔分类E2或E3)或> 30%的结肠粘膜受累(CD,IBD-U);疾病持续时间> 8年,或伴有PSC的患者的任何疾病程度或持续时间;一项“指数”监测结肠镜检查(定义如下),至少3个月后通过允许结肠组织学评估的程序(即至少一次后续监测结肠镜检查或结肠切除标本,或任何类型的程序产生IND诊断或CRN)和;组织学由MSH的专业IBD病理学家进行分析。如果在指数结肠镜检查之前或之内发生ACRN或结肠切除术,则排除患者。没有排除在指数结肠镜检查之前具有IND或LGD病史的患者(以下称为“先前发育不良”)。