Loss 英 /lɒs/ 美 /lɔs/
释 义 n. 减少；亏损；失败；遗失；n. (Loss)人名；(匈)洛什；(法、德、意)洛斯；复数 losses
同根词 lossy adj. 有损耗的；lossless adj. 无损的；loser n. 失败者；遗失者
例 句 We condole with him on his loss. 我们对他的损失深表同情。
释 义 n. [遗] 杂合性；异型接合性
同根词 heterozygous adj. 杂合的
例 句 The other loci showed high diversity and heterozygosity in the populations. 其余的位点均表现出较高的多态性和杂合性。
作者： David B. Dix
期刊：J. Clin. Oncol.
Loss of heterozygosity (LOH) for polymorphic DNA markers seen on chromosomes 1p and 16q was suggested as a prognostic biomarker for Wilms tumor in several retrospective studies. National Wilms Tumor Study 5 (NWTS-5) prospectively evaluated LOH as a prognostic marker in more than 1,700 patients with FHWT. Results showed that LOH at either 1p or 16q was a predictor of increased relapse or death. The greatest effect was seen in patients with combined LOH of 1p and 16q (LOH1p/16q), found in approximately 6% of patients. For patients with stage I/II disease treated with regimen EE4A (vincristine [VCR] and dactinomycin [DACT]), 4-year relapse-free survival with and without LOH1p/16q was 71.9% and 91.2%, respectively (P = .001). For patients with stage III/IV disease treated with regimen DD4A (VCR, DACT, and doxorubicin [DOX]) and radiation therapy (RT), 4-year relapse-free survival with and without LOH1p/16q was 65.9% and 83%, respectively (P = .01). There was no association with the presence or absence of LOH1p/16q and the location of relapse; thus, augmentation with systemic therapy rather than local RT was considered an appropriate intensification strategy.