释 义 n. 替莫唑胺
例 句 At recurrence temozolomide is effective for anaplastic tumors; well-tolerated and probably equally effective is PCV used as adjuvant therapy. 对于复发的病人，替莫唑胺对间变胶质瘤是有效的。作为辅助治疗，它和PCV方案有同等的效果。
作者： Anna F. Farago
Among 50 patients with relapsed SCLC, combination OT shows a strong signal of clinical efficacy. Although cross-study comparisons are difficult to interpret, the confirmed ORR of 41.7% and mPFS of 4.2 months are numerically superior to several recent second- and third-line SCLC studies. The addition of veliparib to temozolomide also showed improved responses in a placebo-controlled randomized phase 2 study, further supporting this strategy. In contrast, monotherapy with the PARP inhibitor talazoparib led to only 2 partial responses among 23 SCLC patients treated in a phase 1 expansion study, and monotherapy olaparib did not confer a PFS benefit compared to placebo when used as a single agent in the maintenance setting after first-line platinum/etoposide. The superiority of the combination over monotherapy was also evident in our PDX models, where OT was significantly more active than either drug alone (Supplementary Figure 2C). Collectively, these data support the further development of strategies that combine induction of DNA damage with PARP inhibition. Such an approach in the SCLC second-line setting is timely, given that standard of care is shifting to incorporate immune checkpoint blockade in combination with EP in the first-line setting.