微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Tumor immune escape
Tumor immune escape

肿瘤

关键词肿瘤 临床研究术语 机制与治疗

词汇介绍

拓展阅读

解析

Tumor   英 /'tju:mə(r)/   美 /'tjʊmɚ/

释    义   n. 肿瘤;肿块;赘生物

例    句   Human tumor cells expressed high levels of growth factor and its receptor . 人类肿瘤细胞表达高水平的生长因子及其受体。

 

Immune   英 /ɪ'mjuːn/   美 /ɪ'mjʊn/

释    义   adj. 免疫的;免于……的,免除的;n. 免疫者;免除者

同根词   immunized adj. 免疫的;immunochemical adj. 免疫化学的;immunity n. 免疫力;豁免权;免除;immunization n. 免疫;immunisation n. 免疫;免疫法;

例    句   "If it works as what we see (in) the immune responses in animals, I think we have a fairly good chance of developing a vaccine that works, " he said in an interview. “如果它能够像我们在动物试验中看到的那样对免疫应答发挥作用,我想我们将有很好的机会去研发一种能够起效的疫苗,”他在采访中说。

 

Escape   英 /ɪ'skeɪp; e-/   美 /ɪˈskep/

释    义   vt. 逃避,避开,避免;被忘掉;被忽视;vi. 逃脱;避开;溜走;(气体,液体等)漏出;(未受伤或只受了一点伤害而)逃脱;声音(不自觉地)由…发出;n. 逃跑;逃亡;逃走;逃跑工具或方法;野生种;泄漏

同根词   escaped adj. 逃走的;逸出的;escapist adj. 逃避现实的;escapement n. 擒纵机构棘轮装置;脱逃;逃亡的出口;卡子;escapism n. 逃避现实,空想;逃避主义;

例    句   How can I escape from all of this? 我怎样才能逃离这些呢?

概述

THOMAS 和 BURNET 在 1975年最先提出的免疫监视学说认为,免疫系统可以监视细胞恶变,并诱导识别、清除恶性细胞。免疫编辑学说认为,编辑是一个动态的过程,可分为消除、相持和逃逸三个阶段。这三个阶段并不是独立的,而是一个连续动态的肿瘤和免疫系统之间相互作用。在肿瘤-免疫过程中,肿瘤细胞必需释放肿瘤抗原刺激和活化效应细胞,肿瘤特异性 T 细胞需渗透进肿瘤组织、识别主要组织相容性复合体(MHC)提呈的癌细胞,从而诱导细胞死亡。但是,在癌症患者中,这一循环不能很好地执行,肿瘤通过多种机制

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation复制标题

癌症酸度: 肿瘤免疫逃逸的终极前沿和免疫调节的新靶点

发表时间:2017-04-01

影响因子:9.7

作者: Veronica Huber

期刊:Semin. Cancer Biol.

One main driver of the metabolic reprogramming occurring in the TME is undoubtedly represented by hypoxia. Cells of both innate and adaptive immunity are highly sensitive to the hypoxic microenvironment featuring most solid cancers, sensing low oxygen availability mainly by the HIF transcriptional system and via other molecular mechanisms. Hypoxia has been shown to regulate aggregation, invasion and motility of macrophages and neutrophils, favoring local inflammation and immunosuppression. Low oxygen tension can also affect T cell differentiation and function, possibly tilting the balance toward a T helper (Th)17/Treg phenotype, and impair cytotoxic properties of NK cells. Of note, hypoxia upregulates immune checkpoints in the TME, promoting tumor immune escape but also increasing the expression of molecular targets for cancer immunotherapy. The multiple and complex hypoxia-driven pathways affecting tumor immune surveillance, that are recently gaining special attention as potential targets of immunomodulation in cancer, have been elegantly and extensively addressed in dedicated reviews.

译文

在TME中发生的代谢重编程的一个主要驱动因素无疑是缺氧。先天性和适应性免疫的细胞对以大多数实体癌为特征的缺氧微环境高度敏感,主要通过HIF转录系统和其他分子机制感知低氧可用性。缺氧已被证明可调节巨噬细胞和中性粒细胞的聚集,侵袭和运动,有利于局部炎症和免疫抑制。低氧张力还可以影响T细胞分化和功能,可能使平衡倾向于T辅助(Th)17 / Treg表型,并损害NK细胞的细胞毒性。值得注意的是,缺氧会上调TME中的免疫检查点,促进肿瘤免疫逃逸,但也会增加癌症免疫治疗的分子靶点的表达。影响肿瘤免疫监视的多种复杂缺氧驱动途径最近作为癌症免疫调节的潜在靶点而受到特别关注,在专门评论中已经得到了优雅和广泛的解决。