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首页 > 医学词汇大全 > Tumor-Infiltrating Dendritic Cells
Tumor-Infiltrating Dendritic Cells

肿瘤

关键词肿瘤 临床研究术语 基础研究

词汇介绍

拓展阅读

解析

Tumor   英 /'tju:mə(r)/   美 /'tjʊmɚ/

释    义   n. 肿瘤;肿块;赘生物

例    句   Results: Nanotechnology has its giant advantage in diagnosis and treatment of tumor. 结果:纳米技术在肿瘤诊断与治疗中有着巨大优势。


Infiltrating    /ɪn'fɪltret/

释    义   v. 渗透;浸润(infiltrate的ing形式);adj. 浸润的;浸润性的

例    句   Objective: To investigate the synergy effects of IL 2 and IL 4 on the proliferation and cytotoxicity of tumor infiltrating lymphocytes (TIL) from murine bladder carcinoma in vitro. 目的探讨白细胞介素(IL) 2与IL 4对膀胱癌肿瘤浸润性淋巴细胞(TIL)体外增殖及细胞毒性免疫调控的协同作用。

 

Dendritic   英 /den'drɪtɪk/   美 /dɛn'drɪtɪk/

释    义   adj. 树枝状的;树状的

同根词   dendrite n. (神经的)[解剖] 树突;树枝石;模树石

例    句   "Dendritic" (treelike) immune cells send branches into the respiratory and digestive tracts, where they sample all the microbes we inhale or swallow. “树突状”(树状)免疫细胞将支脉送至我们吸入或者吞下微生物呼吸道和消化道对它们进行采样。


Cells

释    义   n. [细胞] 细胞;单元格(cell的复数);牢房;小屋;v. 住在牢房中(cell的三单形式)

例    句   We found some cells in your lymph nodes, in three of them. 我们在你的三个淋巴结里发现了一些细胞。

概述

树突状细胞(DCs)是最具潜能的抗原提呈细胞,它能激活初始型T细胞,在启动抗瘤免疫应答中扮演着重要角色。1973年,Steinman和Cohn第一次从小鼠的淋巴器官中发现并分离出了树突状细胞。从此,树突状细胞一直受到免疫学界的关注。近年来,关于DC在肿瘤免疫中的作用引起了人们的注意,研究表明,肿瘤微环境中的免疫状态往往比外周血免疫功能更能确切反映宿主的抗瘤免疫状态。肿瘤浸润性树突状细胞(TIDCs)是功能低下或无功能的树突状细胞,肿瘤细胞分泌的免疫抑制因子对其表型特征的改变可能是致使其功能低

Human Tumor-Infiltrating Dendritic Cells: From In Situ Visualization to High-Dimensional Analyses复制标题

人肿瘤浸润树突状细胞: 从原位可视化到高维分析

发表时间:2019-07-30

影响因子:6.2

作者: Margaux Hubert

期刊:Cancers

The interaction between tumor cells and the immune system is considered to be a dynamic process. Dendritic cells (DCs) play a pivotal role in anti-tumor immunity owing to their outstanding T cell activation ability. Their functions and activities are broad ranged, triggering different mechanisms and responses to the DC subset. Several studies identified in situ human tumor-infiltrating DCs by immunostaining using a limited number of markers. However, considering the heterogeneity of DC subsets, the identification of each subtype present in the immune infiltrate is essential. To achieve this, studies initially relied on flow cytometry analyses to provide a precise characterization of tumor-associated DC subsets based on a combination of multiple markers. The concomitant development of advanced technologies, such as mass cytometry or complete transcriptome sequencing of a cell population or at a single cell level, has provided further details on previously identified populations, has unveiled previously unknown populations, and has finally led to the standardization of the DCs classification across tissues and species. Here, we review the evolution of tumor-associated DC description, from in situ visualization to their characterization with high-dimensional technologies, and the clinical use of these findings specifically focusing on the prognostic impact of DCs in cancers.

译文

肿瘤细胞和免疫系统之间的相互作用被认为是一个动态过程。树突状细胞(DC)由于其突出的T细胞活化能力而在抗肿瘤免疫中起关键作用。它们的功能和活动范围很广,触发了不同的机制和对DC子集的响应。一些研究使用有限数量的标记物通过免疫染色鉴定了原位人肿瘤浸润性DC。然而,考虑到DC亚群的异质性,免疫浸润中存在的每种亚型的鉴定是必需的。为了实现这一目标,研究最初依赖于流式细胞术分析,以基于多种标记的组合提供肿瘤相关DC亚群的精确表征。先前技术的相应发展,例如质量细胞计数或细胞群的完整转录组测序或单细胞水平,已经提供了关于先前鉴定的群体的进一步细节,揭示了先前未知的群体,并且最终导致了标准化。跨组织和物种的DC分类。在这里,我们回顾肿瘤相关DC描述的演变,从原位可视化到高维技术的表征,以及这些发现的临床应用,特别关注DC在癌症中的预后影响。