肿瘤
词汇介绍
拓展阅读
解析
Tumor 英 /'tju:mə(r)/ 美 /'tjʊmɚ/
释 义 n. 肿瘤;肿块;赘生物
例 句 Results: Nanotechnology has its giant advantage in diagnosis and treatment of tumor. 结果:纳米技术在肿瘤诊断与治疗中有着巨大优势。
Infiltrating /ɪn'fɪltret/
释 义 v. 渗透;浸润(infiltrate的ing形式);adj. 浸润的;浸润性的
例 句 Objective: To investigate the synergy effects of IL 2 and IL 4 on the proliferation and cytotoxicity of tumor infiltrating lymphocytes (TIL) from murine bladder carcinoma in vitro. 目的探讨白细胞介素(IL) 2与IL 4对膀胱癌肿瘤浸润性淋巴细胞(TIL)体外增殖及细胞毒性免疫调控的协同作用。
Dendritic 英 /den'drɪtɪk/ 美 /dɛn'drɪtɪk/
释 义 adj. 树枝状的;树状的
同根词 dendrite n. (神经的)[解剖] 树突;树枝石;模树石
例 句 "Dendritic" (treelike) immune cells send branches into the respiratory and digestive tracts, where they sample all the microbes we inhale or swallow. “树突状”(树状)免疫细胞将支脉送至我们吸入或者吞下微生物呼吸道和消化道对它们进行采样。
Cells
释 义 n. [细胞] 细胞;单元格(cell的复数);牢房;小屋;v. 住在牢房中(cell的三单形式)
例 句 We found some cells in your lymph nodes, in three of them. 我们在你的三个淋巴结里发现了一些细胞。
概述
Human Tumor-Infiltrating Dendritic Cells: From In Situ Visualization to High-Dimensional Analyses复制标题
人肿瘤浸润树突状细胞: 从原位可视化到高维分析
发表时间:2019-07-30
影响因子:6.2
作者: Margaux Hubert
期刊:Cancers
The interaction between tumor cells and the immune system is considered to be a dynamic process. Dendritic cells (DCs) play a pivotal role in anti-tumor immunity owing to their outstanding T cell activation ability. Their functions and activities are broad ranged, triggering different mechanisms and responses to the DC subset. Several studies identified in situ human tumor-infiltrating DCs by immunostaining using a limited number of markers. However, considering the heterogeneity of DC subsets, the identification of each subtype present in the immune infiltrate is essential. To achieve this, studies initially relied on flow cytometry analyses to provide a precise characterization of tumor-associated DC subsets based on a combination of multiple markers. The concomitant development of advanced technologies, such as mass cytometry or complete transcriptome sequencing of a cell population or at a single cell level, has provided further details on previously identified populations, has unveiled previously unknown populations, and has finally led to the standardization of the DCs classification across tissues and species. Here, we review the evolution of tumor-associated DC description, from in situ visualization to their characterization with high-dimensional technologies, and the clinical use of these findings specifically focusing on the prognostic impact of DCs in cancers.
译文