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首页 > 医学词汇大全 > borderline tumor
borderline tumor

肿瘤

关键词肿瘤 疾病 肿瘤

词汇介绍

拓展阅读

解析

Borderline   英 /'bɔːdəlaɪn/   美 /'bɔrdɚlaɪn/

释    义   adj. 临界的;边界的;所属不清的;暧昧的;n. 边界线,边界;中间地带;暧昧状态;adv. 几乎;差不多;复数 borderlines

同根词   border n. 边境;边界;国界;border n. 接界;近似;border n. 接近;与…接壤;在…上镶边

例    句   Conclusion: MRI is able to display size, shape, borderline and signal characteristics of tumors in clivus chordoma, contributing to diagnosis of them. 结论:MRI可以准确显示斜坡脊索瘤的大小、形态、边界和信号特点,有利于该病的诊断。

 

Tumor   英 /'tju:mə(r)/   美 /'tjʊmɚ/

释    义   n. 肿瘤;肿块;赘生物

例    句   The concept of cancer stem cells may have profound implications for our understanding of tumor biology and for the design of novel treatments targeted toward these cells. 肿瘤干细胞的概念对于我们理解肿瘤生物学和构思针对这类细胞的靶向治疗来说,可能有着更加深远的意义。

概述

肿瘤是人体某种细胞发生异常再生达到一定数目形成的肿块。肿瘤有良性和恶性之分,良性肿瘤特点是不复发,不转移,预后良好。恶性肿瘤生长迅速,浸润广泛,容易转移,危及生命。介于良恶性肿瘤之间的称为交界性肿瘤,交界性肿瘤是一种低度潜在恶性肿瘤,它同时具有良性肿瘤和恶性肿瘤的一些特征,如生长缓慢,复发迟,类似良性肿瘤,但它又可以发生转移,只不过转移率较低,鉴于这种肿瘤的特征处于良性和恶性之间,所以叫交界性肿瘤。交界性肿瘤有如下3种表现形式:肿瘤细胞的形态(显微镜下所见)介于良性、恶性肿瘤之间;肿瘤细胞的

A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases复制标题

免疫组化标记物CK7和SATB2的组合对于鉴别原发性卵巢粘液性肿瘤与结直肠和阑尾转移具有高度敏感性和特异性。

发表时间:2019-06-25

影响因子:6.4

作者: Nicola S. Meagher

期刊:Mod. Pathol.

Primary ovarian mucinous tumors can be difficult to distinguish from metastatic gastrointestinal neoplasms by histology alone. The expected immunoprofile of a suspected metastatic lower gastrointestinal tumor is CK7-/CK20+/CDX2+/PAX8-. This study assesses the addition of a novel marker SATB2, to improve the diagnostic algorithm. A test cohort included 155 ovarian mucinous tumors (105 carcinomas and 50 borderline tumors) and 230 primary lower gastrointestinal neoplasms (123 colorectal adenocarcinomas and 107 appendiceal neoplasms). All cases were assessed for SATB2, PAX8 CK7, CK20, and CDX2 expression on tissue microarrays. Expression was scored in a 3-tier system as absent, focal (1-50% of tumor cells) and diffuse ( >50% of tumor cells) and then categorized into either absent/present or nondiffuse/diffuse. SATB2 and PAX8 expression was further evaluated in ovarian tumors from an international cohort of 2876 patients (expansion cohort, including 159 mucinous carcinomas and 46 borderline mucinous tumors). The highest accuracy of an individual marker in distinguishing lower gastrointestinal from ovarian mucinous tumors was CK7 (91.7%, nondiffuse/diffuse cut-off) followed by SATB2 (88.8%, present/absent cut-off). The most effective combination was CK7 and SATB2 with accuracy of 95.3% using the 3-tier interpretation, absent/focal/diffuse.

译文

通过单独的组织学,原发性卵巢粘液性肿瘤难以与转移性胃肠肿瘤区分开。疑似转移性下胃肠道肿瘤的预期免疫表型是CK7- / CK20 + / CDX2 + / PAX8-。该研究评估了新标记SATB2的添加,以改进诊断算法。一个测试队列包括155个卵巢粘液性肿瘤(105个癌和50个临界肿瘤)和230个原发性下胃肠道肿瘤(123个结肠直肠腺癌和107个阑尾肿瘤)。评估所有病例的组织微阵列上的SATB2,PAX8 CK7,CK20和CDX2表达。表达在3层系统中评分为不存在,局灶性(1-50%的肿瘤细胞)和弥漫性(> 50%的肿瘤细胞),然后分类为缺失/存在或非扩散/弥散。在来自2876名患者的国际队列(扩增队列,包括159个粘液性癌和46个边缘粘液性肿瘤)的卵巢肿瘤中进一步评估SATB2和PAX8表达。区分下胃肠道和卵巢粘液性肿瘤的个体标志物的最高准确度是CK7(91.7%,非扩散/弥散性截断),其次是SATB2(88.8%,存在/不存在截止值)。最有效的组合是CK7和SATB2,使用3层解释,没有/焦点/弥散,准确率为95.3%。