肿瘤
词汇介绍
拓展阅读
解析
Multidrug
释 义 n. 多药
例 句 The essence of the elimination strategy to cure leprosy, avoid disability andreduce the disease burden is to detect all patients as early as possible, and to treat them with multidrug treatment. 为治愈麻风、避免残疾和减轻疾病负担所制定的消灭战略,其精髓在于及早发现所有患者,并对他们采用多药性疗法进行治疗。
Resistance 英 /rɪ'zɪst(ə)ns/ 美 /rɪ'zɪstəns/
释 义 n. 阻力;电阻;抵抗;反抗;抵抗力;复数 resistances
同根词 resistant adj. 抵抗的,反抗的;顽固的;resistive adj. 有抵抗力的;resistible adj. 可抵抗的;resistless adj. 无抵抗力的;无法抗拒的;resist [助剂] n. 抗蚀剂;防染剂;resistant n. 抵抗者;
例 句 You have the ability to look here where there is not resistance. 你有能力在没有阻力的地方观察。
概述
Repurposing approved drugs on the pathway to novel therapies复制标题
将批准的药物重新用于新疗法的途径
发表时间:2019-08-20
影响因子:9.8
作者: Catherine H. Schein
期刊:Med Res Rev
The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many "repurposed" drugs, such as derivatives of thalidomide, antibiotics, and antivirals have had clinical success in treatment areas well beyond their original approved use. These include applications in treating antibiotic-resistant organisms, viruses, cancers and to prevent burn scarring. The major theoretical justification for reusing approved drugs is that they have known modes of action and controllable side effects. Coadministering antibiotics with inhibitors of bacterial toxins or enzymes that mediate multidrug resistance can greatly enhance their activity. Drugs that control host cell pathways, including inflammation, tumor necrosis factor, interferons, and autophagy, can reduce the "cytokine storm" response to injury, control infection, and aid in cancer therapy. An active compound, even if previously approved for human use, will be a poor clinical candidate if it lacks specificity for the new target, has poor solubility or can cause serious side effects. Synergistic combinations can reduce the dosages of the individual components to lower reactivity. Preclinical analysis should take into account that severely ill patients with comorbidities will be more sensitive to side effects than healthy trial subjects.
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