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Long-term outcome of image-guided percutaneous radiofrequency ablation of lung metastases: an open-labeled prospective trial of 148 patients.
图像引导下经皮射频消融肺转移的长期结果: 一项对 148 名患者的开放标记前瞻性试验。

摘要

BACKGROUND:Image-guided percutaneous radiofrequency ablation (RFA) has been proposed as an efficacious local therapy for lung metastases in nonsurgical candidates. Reports of long-term outcome from this treatment have been limited.
METHODS:A prospective open-labeled trial of RFA was initiated in November 2000 for treatment of lung metastases in nonsurgical candidates. RFA was carried out under fluoroscopic computed tomography. Treatment complications and survival parameters were analyzed.
RESULTS:Of 148 patients treated, 66 patients (46%) had a complete response, 38 patents (26%) had a partial response, 57 patients (39%) had stable disease and 23 patients (16%) had progressive disease. The median progression-free survival was 11 months [95% confidence interval (CI) 9-14]. The median overall survival and 3- and 5-year survivals were 51 months (95% CI 19-83) and 60% and 45%, respectively. Disease-free interval (P = 0.013) and response to treatment (P = 0.002) were independent predictors for overall survival. Complications occurred in up to 45% of patients, of which 45 patients (30%) required chest tube placement.
CONCLUSION:This analysis confirms that RFA of lung metastases may achieve long-term survival in nonsurgical candidates with an acceptable complication rate hence supporting its incorporation into the oncosurgical management of lung metastases for the purposes of cure, stabilization and disease prolongation.

译文

背景: 图像引导下经皮射频消融 (RFA) 已被提出作为非手术候选肺转移的有效局部治疗。这种治疗的长期结果报告有限。
方法: 2000年11月开始了一项前瞻性开放标记 RFA 试验,用于治疗非手术候选肺转移。RFA 是在透视计算机断层扫描下进行的。分析治疗并发症和生存参数。
结果: 在 148 名接受治疗的患者中,66 名患者 (46%) 有完全反应,38 名患者 (26%) 有部分反应,57 名患者 (39%) 病情稳定,23 名患者 (16%) 病情进展。中位无进展生存期为 11 个月 [95% 置信区间 (CI) 9-14]。中位总生存期和 3 年和 5 年生存期分别为 51 个月 (95% CI 19-83) 和 60% 和 45%。无病间期 (P = 0.013) 和治疗反应 (P = 0.002) 是总生存期的独立预测因素。高达 45% 的患者出现并发症,其中 45 名患者 (30%) 需要放置胸管。
结论: 这一分析证实了肺转移的 RFA 可能在非手术的候选患者中获得长期生存,并具有可接受的并发症发生率,因此支持将其纳入肺转移的外科治疗中,以达到治愈的目的。稳定和疾病延长。

percutaneous radiofrequency ablation

肿瘤 肿瘤消融 治疗方法
概述  :  

经皮肿瘤消融(percutaneous tumor ablation)是指在明确肿瘤的部位和性质后,在CT或B超的导向之下,准确穿刺命中靶点——肿瘤,利用物理或化学的方法直接消灭或融解癌组织。消融又分为物理消融和化学消融。物理消融是进行肿瘤穿刺后放入微波天线或者射频电极,利用电磁波在组织内进行加热的原理,使癌组织凝固坏死,经皮射频消融治疗就是其中一种物理消融的方法。射频是一定特定频率的电磁波,医用射频频率为460-500 KHz。医用射频电磁波可激活组织内部的极性分子产生电磁振荡产

Percutaneous   英 /,pɜːkjʊ'teɪnɪəs/   美 /,pɝkju'tenɪəs/

       adj. 经皮的;经由皮肤的

       Objective: TO investigate the nursing and observation of bleeding after percutaneous coronary interventions (PCI), so as to alleviate the painful and treat the complication of bleeding in time. 目的:探讨经皮冠状动脉介入术后出血并发症的观察与护理,以减轻病人的痛苦,减少和及时处理术后出血并发症。

 

Radiofrequency   /,reidiəu-'fri:kwənsi/

       n. 高频,射频;高周波

       Mobile phones are often prohibited in hospitals and on airplanes, as the radiofrequency signals may interfere with certain electro-medical devices and navigation systems. 由于射频信号可能会干扰某些电子医疗装置和导航系统,在医院里和飞机上通常禁止使用移动电话。

 

Ablation   英 /ə'bleɪʃ(ə)n/   美 /ə'bleʃən/

       n. [水文] 消融;切除

同根词   ablative adj. 离格的;消融的;ablative n. 烧蚀材料;离格;

       But if these go to plan, fewer procedures like cardiac ablation will need to be repeated, lowering the number of readmissions, and with it cost of treatment. 不过如果一切都按计划进行,那么心脏消融术重复的次数就可以减少,从而降低再次入院的次数和治疗费用。

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