肿瘤
词汇介绍
拓展阅读
解析
Platelet 英 /'pleɪtlɪt/ 美 /'pletlət/
释 义 n. [组织] 血小板；薄片
例 句 Objective: To observe the effect of aspirin on blood lipid and platelet aggregation in atherosclerotic rabbits with hyperlipidemia, and the relationship between them. 目的：观察阿司匹林对高脂性动脉粥样硬化兔血脂和血小板聚集的影响以及两者之间的相互关系。
Derived 英 /dɪ'raɪvd/ 美 /dɪ'raɪvd/
释 义 adj. 导出的；衍生的，派生的；v. 从……衍生出，源于；（从……中）得到，提取；导出（derive 的过去式和过去分词）
同根词 derivative adj. 派生的；引出的；derivational adj. 得来的；诱导的；derivative n. [化学] 衍生物，派生物；
例 句 All they know and deal with is derived from experience. 它们所知道的和所处理的，都是从经验得出来的。
Growth 英 /grəʊθ/ 美 /ɡroθ/
释 义 n. 增长；发展；生长；种植
同根词 grown adj. 长大的；成年的；长满某物的；growing adj. 发展的；成长的；
例 句 But during their growth period. 但是在生长的期间。
Factor 英 /'fæktə/ 美 /'fæktɚ/
释 义 n. 因素；要素；[物] 因数；代理人；vi. 做代理商；vt. 把…作为因素计入；代理经营；把…分解成
同根词 factory n. 工厂；制造厂；代理店；factoring n. [数] 因子分解，[数] 因式分解；保付代理；factorization n. [数] 因子分解；[数] 因式分解；
例 句 But this cannot be the only factor. 但这不可能是唯一的因素。
概述
复制标题帕唑帕尼或甲氨蝶呤-长春碱联合化疗治疗成人进展性硬纤维瘤 (DESMOPAZ): 一项非比较、随机、开放标签、多中心、2期研究
发表时间：2019-07-19
影响因子：35.4
作者： Maud Toulmonde
期刊：Lancet Oncol.
The mechanism of action of multityrosine kinase inhibitors such as pazopanib or sorafenib in desmoid tumours is not known. A post-hoc proteomic analysis of pretreatment samples allowed the identification of several proteins significantly overexpressed in patients with an objective response to pazopanib compared with patients with no objective response. Differentially expressed proteins in patients with an objective response were involved in angiogenesis regulation and various processes such as cell-to-cell and cell-to-matrix inter actions, cellular proliferation, migration, adhesion and attachment, vascular inflammation, including notably thrombo- spondin-4 and platelet-derived growth factor receptor-like protein. Importantly, among the most differentially expressed proteins in the responding patient group were PDGF receptor-like protein and thrombospondin-4. Sustained expression and phos phorylation of PDGFR alpha and PDGFR beta on immunohistochemistry have been reported in aggressive desmoid tumours, and this is believed to occur within an autocrine or paracrine loop mediated by cyclo-oxygenase-2 overexpression and deregulation of the APC-β-catenin signalling pathway. Thrombospondin-4 is an important proangiogenic factor that contributes to tumour growth via TGF-β pathway activation, which mediates Wnt/β-catenin signalling in desmoid tumours.
译文