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首页 > 医学词汇大全 > Tumor Infiltrating Lymphocytes
Tumor Infiltrating Lymphocytes

肿瘤

关键词肿瘤 临床研究术语 异质细胞

词汇介绍

拓展阅读

解析

Tumor   英 /'tju:mə(r)/   美 /'tjʊmɚ/

       n. 肿瘤;肿块;赘生物

       Tumor growth in the body though is a local.  肿瘤虽然是生长在身体的某一局部。

 

Infiltrating   /ɪn'fɪltret/

       v. 渗透;浸润(infiltrate的ing形式)

               adj. 浸润的;浸润性的

       Angiogenesis is correlated to growth, infiltrating and metastasis of renal cell carcinoma (RCC).  肾细胞癌的生长、浸润和转移与血管生成密切相关。

 

Lymphocyte   英 /'lɪmfə(ʊ)saɪt/   美 /'lɪmfə'saɪt/ 

       n. [免疫] 淋巴细胞;淋巴球

       Lymphocyte is a kind of leucocyte of small volume.  淋巴细胞是一种体积较小的白细胞。

概述

TILs是指从肿瘤组织中分出出来的浸润淋巴细胞,是一群异质细胞,主要为CD3阳性T细胞,包括CD4阳性及CD8阳性T细胞。目前研究表明肿瘤组织中TILs细胞数量与肿瘤患者治疗及预后存在相关性。同时TILs细胞中具有能够特异识别和杀伤肿瘤的T细胞,通过分离纯化肿瘤组织中的TILs,体外经IL-2扩增培养后回输患者体内,能够治疗和消除转移性肿瘤。因此,其也用于转移性肿瘤治疗,即为TILs细胞疗法,属于过继性免疫细胞治疗的一种。 原理肿瘤浸润淋巴细胞TILs最早由Rosenberg等于1

Unique neoantigens arise from somatic mutations in patients with gastrointestinal cancers复制标题

独特的新抗原来源于胃肠道癌症患者的体细胞突变。

发表时间:2019-06-04

影响因子:24.4

作者: Maria R. Parkhurst

期刊:Cancer Discov

Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes that recognize mutant proteins expressed by autologous tumors which may represent ideal targets for immunotherapy. Using high throughput immunologic screening of mutant gene products identified via whole exome sequencing, we identified neoantigen reactive tumor infiltrating lymphocytes (TIL) from 62 of 75 (83%) patients with common gastrointestinal cancers. In total, 124 neoantigen reactive TIL populations were identified, and all but one of the neoantigenic determinants were unique. The results of in vitro T cell recognition assays demonstrated that 1.6% of the gene products encoded by somatic non-synonymous mutations were immunogenic. These findings demonstrate that the majority of common epithelial cancers elicit immune recognition and open possibilities for cell based immunotherapies for patients bearing these cancers.

译文

免疫疗法可以介导具有高突变率的人类肿瘤的消退,但在患有常见上皮癌的患者中很少观察到反应。这引发了这样的问题:患有这些常见癌症的患者是否具有识别由自体肿瘤表达的突变蛋白的T淋巴细胞,其可以代表免疫疗法的理想靶标。使用通过全外显子组测序鉴定的突变基因产物的高通量免疫筛选,我们从75名患有常见胃肠癌的患者中的62名(83%)中鉴定了新抗原反应性肿瘤浸润淋巴细胞(TIL)。总共鉴定了124个新抗原反应性TIL群体,除了一个新抗原决定簇之外的所有群体都是独特的。体外T细胞识别测定的结果表明,由体细胞非同义突变编码的1.6%的基因产物是免疫原性的。这些发现表明,大多数常见的上皮癌为携带这些癌症的患者引发免疫识别和基于细胞的免疫疗法的开放可能性。