circulating 美 /'sɝkjə,letɪŋ/
释 义 adj. 循环的；流通的；v. 循环（circulate的ing形式）；流通
例 句 ach pound of refrigerant circulating in the system must do its share of the work. 在系统的循环中，每磅制冷剂必须完成本份的工作。
释 义 脱氧核糖核酸，基因，遗传物质
例 句 Well, you know, we have to protect our DNA. 好的，你知道，我们必须保护自己的DNA。
作者： Vincent P. Groot
期刊：Clin. Cancer Res.
A clinical validation of a KRAS circulating tumor DNA (ctDNA) assay was performed in a Clinical Laboratory Improvement Amendments (CLIA) certified and College of American Pathology (CAP) inspected clinical laboratory. This study confirmed the clinical utility of ctDNA as a tumor- specific biomarker for prognostic stratification and monitoring of tumor dynamics in patients with pancreatic cancer. First, detection of mutant KRAS ctDNA prior to surgery or in the immediate post-operative period predicts a higher likelihood of tumor recurrence and poorer survival. Second, rising mutant KRAS ctDNA during post-operative follow-up anticipates radiographic/clinical recurrence with a lead time of 84 days. As a result of this study, this KRAS ctDNA test is now live at the Johns Hopkins Hospital (go live date, 12/4/2018). Future prospective and interventional trials will determine if treatment decisions based on ctDNA dynamics can improve patient outcomes.