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cancer chemoprevention

肿瘤

关键词肿瘤 治疗方法 肿瘤预防

词汇介绍

拓展阅读

解析

Cancer   英 /'kænsə/   美 /kænsə/

       n. 癌症;恶性肿瘤

同根词   cancerous adj. 癌的;生癌的;像癌的

       But what of those who have not been diagnosed with cancer? 但是那些没有被诊断患癌症的人怎么办呢?

 

Chemoprevention   /,keməupri'venʃən/

       n. 化学预防

       Conclusion Arotinoid ethylester has an inhibitory effect on ODC and PCNA by which it inhibits skin papilloma in mouse. Arotinoid ethylester possesses the effect of cancer chemoprevention. 结论芳维A酸乙酯对ODC、PCNA的抑制作用是其预防小鼠乳头状瘤发生的重要机制,它具有抗癌化学预防作用。

概述

目前,癌症已成为严重威胁我国以及全世界的常见疾病,位居疾病死因之首。据报道,未来20-30年,中国的癌症死亡率仍将继续上升。造成这一现状的一个主要原因是80%的癌症患者在发现时已是晚期,错过了最佳治疗时机。研究表明,早期发现癌症,绝大部分可以得到有效的治疗甚至治愈,5年生存率可达到80%。但是晚期癌症患者,5年生存率不足10%。早在上世纪80年代,WHO就提出了3个1/3观点,即1/3的癌症可以预防、1/3的癌症患者可以治愈、1/3的癌症患者经过积极治疗后可以提高生活质量,延长生存期。癌症化

Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment复制标题

癌症化学预防重访: 细胞色素P450家族1B1作为肿瘤和微环境中的靶点

发表时间:2018-02-01

影响因子:8.3

作者: Gabriele D’Uva

期刊:Cancer Treat. Rev.

Cancer chemoprevention is the use of synthetic, natural or biological agents to prevent or delay the development or progression of malignancies. Intriguingly, many phytochemicals with anti-inflammatory and anti-angiogenic effects, recently proposed as chemoprevention strategies, are inhibitors of Cytochrome P450 family 1B1 (CYP1B1), an enzyme overexpressed in a wide variety of tumors and associated with angiogenesis. In turn, pro-inflammatory cytokines were reported to boost CYP1B1 expression, suggesting a key role of CYP1B1 in a positive loop of inflammatory angiogenesis. Other well-known pro-tumorigenic activities of CYP1B1 rely on metabolic bioactivation of xenobiotics and steroid hormones into their carcinogenic derivatives. In contrast to initial in vitro observations, in vivo studies demonstrated a protecting role against cancer for the other CYP1 family members (CYP1A1 and CYP1A2), suggesting that the specificity of CYP1 family inhibitors should be carefully taken into account for developing potential chemoprevention strategies. Recent studies also proposed a role of CYP1B1 in multiple cell types found within the tumor microenvironment, including fibroblasts, endothelial and immune cells. Overall, our review of the current literature suggests a positive loop between inflammatory cytokines and CYP1B1, which in turn may play a key role in cancer angiogenesis, acting on both cancer cells and the tumor microenvironment.

译文

癌症化学预防是使用合成,天然或生物制剂来预防或延迟恶性肿瘤的发展或进展。有趣的是,许多具有抗炎和抗血管生成作用的植物化学物质,最近被提出作为化学预防策略,是细胞色素P450家族1B1(CYP1B1)的抑制剂,CYP1B1是一种在多种肿瘤中过表达并与血管生成相关的酶。反过来,据报道促炎细胞因子促进CYP1B1表达,表明CYP1B1在炎性血管生成的阳性环中起关键作用。 CYP1B1的其他众所周知的促肿瘤发生活性依赖于异生素和类固醇激素对其致癌衍生物的代谢生物活化。与最初的体外观察相反,体内研究证明了其他CYP1家族成员(CYP1A1和CYP1A2)对癌症的保护作用,这表明CYP1家族抑制剂的特异性应该被仔细考虑用于开发潜在的化学预防策略。最近的研究还提出了CYP1B1在肿瘤微环境中发现的多种细胞类型中的作用,包括成纤维细胞,内皮细胞和免疫细胞。总体而言,我们对当前文献的回顾表明炎性细胞因子和CYP1B1之间存在正向循环,而CYP1B1又可能在癌症血管生成中发挥关键作用,对癌细胞和肿瘤微环境起作用。