Cancer 英 /'kænsə/ 美 /kænsə/
释 义 n. 癌症；恶性肿瘤
同根词 cancerous adj. 癌的；生癌的；像癌的
例 句 But what of those who have not been diagnosed with cancer? 但是那些没有被诊断患癌症的人怎么办呢？
释 义 n. 化学预防
例 句 Conclusion Arotinoid ethylester has an inhibitory effect on ODC and PCNA by which it inhibits skin papilloma in mouse. Arotinoid ethylester possesses the effect of cancer chemoprevention. 结论芳维A酸乙酯对ODC、PCNA的抑制作用是其预防小鼠乳头状瘤发生的重要机制，它具有抗癌化学预防作用。
作者： Gabriele D’Uva
期刊：Cancer Treat. Rev.
Cancer chemoprevention is the use of synthetic, natural or biological agents to prevent or delay the development or progression of malignancies. Intriguingly, many phytochemicals with anti-inflammatory and anti-angiogenic effects, recently proposed as chemoprevention strategies, are inhibitors of Cytochrome P450 family 1B1 (CYP1B1), an enzyme overexpressed in a wide variety of tumors and associated with angiogenesis. In turn, pro-inflammatory cytokines were reported to boost CYP1B1 expression, suggesting a key role of CYP1B1 in a positive loop of inflammatory angiogenesis. Other well-known pro-tumorigenic activities of CYP1B1 rely on metabolic bioactivation of xenobiotics and steroid hormones into their carcinogenic derivatives. In contrast to initial in vitro observations, in vivo studies demonstrated a protecting role against cancer for the other CYP1 family members (CYP1A1 and CYP1A2), suggesting that the specificity of CYP1 family inhibitors should be carefully taken into account for developing potential chemoprevention strategies. Recent studies also proposed a role of CYP1B1 in multiple cell types found within the tumor microenvironment, including fibroblasts, endothelial and immune cells. Overall, our review of the current literature suggests a positive loop between inflammatory cytokines and CYP1B1, which in turn may play a key role in cancer angiogenesis, acting on both cancer cells and the tumor microenvironment.