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premalignant lesion

肿瘤

关键词肿瘤 临床研究术语 基础研究

词汇介绍

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解析

Premalignant   /,pri:mə'liɡnənt/

       adj. 恶化前的;癌变前的

       Yet is the premalignant lesion the readily recognized intestinal metaplasia or the more difficult to detect dysplasia? 然而癌前病变是已经公认的肠化生还是更难于探及的不典型增生?

 

Lesion   英 /'liːʒ(ə)n/   美 /'liːʒ(ə)n/

       n. 损害;身体上的伤害;机能障碍

       Therefore, the investigators used it to create a "virtual lesion, " or "block" the influence of the healthy hemisphere and depress inhibition on the affected side of the brain. 因此,研究人员用它建立一种“虚拟损伤”或“阻断”健康的大脑半球的影响,并且消弱受影响一侧大脑所受的抑制。

概述

癌前病变,就是癌症出现前的一种疾病形态,常见的有萎缩性胃炎、胃溃疡、胃肠息肉、肝硬化等等。虽然癌前病变还不是癌症,但如果不被重视的话,也有很大的几率发展成癌症。如萎缩性胃炎就有可能发展为胃癌,宫颈糜烂也有可能发展成宫颈癌,Barrett食管可发展成食管癌等等。癌症的发生、发展是由量变到质变、长期演变的过程,大致为正常组织、癌前病变(轻度非典型增生-高度非典型增生/原位癌)、浸润性肿瘤(即癌症)。其中癌前病变及非典型增生即可向正常组织恢复,也可以向癌症恶化,细胞变异程度越低,向正常组织转归的比

The immune contexture associates with the genomic landscape in lung adenomatous premalignancy复制标题

免疫环境与肺腺瘤癌前病变的基因组景观相关联

发表时间:2019-05-29

影响因子:8.4

作者: Kostyantyn Krysan

期刊:Cancer Res.

Epithelial cells in the field of lung injury can give rise to distinct premalignant lesions that may bear unique genetic aberrations. A subset of these lesions may escape immune surveillance and progress to invasive cancer, however the mutational landscape that may predict progression has not been determined. Knowledge of premalignant lesion composition and the associated microenvironment are critical for understanding tumorigenesis and the development of effective preventive and interception strategies. To identify somatic mutations and the extent of immune cell infiltration in adenomatous premalignancy and associated lung adenocarcinomas, we sequenced exomes from 41 lung cancer resection specimens including 89 premalignant atypical adenomatous hyperplasia lesions, 15 adenocarcinomas in situ, and 55 invasive adenocarcinomas and their adjacent normal lung tissues. We defined non-synonymous somatic mutations occurring in both premalignancy and the associated tumor as progression-associated mutations whose predicted neoantigens were highly correlated with infiltration of CD8+ and CD4+ T cells as well as upregulation of PD-L1 in premalignant lesions, suggesting the presence of an adaptive immune response to these neoantigens. Each patient had a unique repertoire of somatic mutations and associated neoantigens. Collectively, these results provide evidence for mutational heterogeneity, pathway dysregulation, and immune recognition in pulmonary premalignancy.

译文

肺损伤领域的上皮细胞可以产生可能具有独特遗传畸变的明显的癌前病变。这些病变的一部分可能逃避免疫监视并进展为侵袭性癌症,但是可能预测进展的突变景观尚未确定。对癌前病变组成和相关微环境的了解对于理解肿瘤发生和有效预防和拦截策略的发展至关重要。为了鉴定腺瘤性癌前病变和相关肺腺癌中的体细胞突变和免疫细胞浸润程度,我们对来自41个肺癌切除标本的外显子组进行了测序,包括89个癌前期非典型腺瘤性增生病变,15个原位腺癌和55个侵袭性腺癌及其相邻的正常肺。组织。我们将在癌前病变和相关肿瘤中发生的非同义体细胞突变定义为进展相关突变,其预测的新抗原与CD8 +和CD4 + T细胞的浸润高度相关,以及在癌前病变中PD-L1的上调,表明存在对这些新抗原的适应性免疫应答。每位患者都有独特的体细胞突变和相关的新抗原库。总的来说,这些结果为肺癌前期的突变异质性,途径失调和免疫识别提供了证据。