首页 > 肿瘤医学词汇大全 > premalignant lesion
Treatment to sustain a Th17-type phenotype to prevent skewing toward Treg and to limit premalignant lesion progression to cancer.
维持 Th17-type 表型的治疗,以防止向调节性 t 细胞倾斜,并限制癌前病变进展为癌症。
HNSCC IL-17 Th17 Treg head and neck cancer premalignant oral lesions
下载

摘要

While immune suppression is a hallmark of head and neck squamous cell carcinoma (HSNCC), the immunological impact of premalignant oral lesions, which often precedes development of HNSCC, is unknown. The present study assessed the changes in splenic and draining lymph node CD4(+) cell populations and their production of select cytokines that occur in mice with carcinogen-induced premalignant oral lesions and the changes that occur as lesions progress to oral cancer. These studies found skewing toward Th1 and Th17-type phenotypes in the spleen and lymph nodes of mice with premalignant oral lesions and a shift to Treg as lesions progress to cancer. Since the role of Th17 cells in the progression from premalignant lesions to cancer is not clear, studies determined the immunological and clinical effect of treating mice bearing premalignant oral lesions with a TGF-β type 1 receptor inhibitor plus IL-23 as an approach to sustain the Th17 phenotype. These studies showed that the treatment approach not only sustained the Th17 phenotype, but also increased distal spleen cell and regional lymph node cell production of other stimulatory/inflammatory mediators and slowed premalignant lesion progression to cancer. 

译文

虽然免疫抑制是头颈部鳞状细胞癌 (HSNCC) 的一个标志,但通常先于 HNSCC 发展的口腔癌前病变的免疫影响是未知的。本研究评估了脾脏和引流淋巴结 CD4 的变化 () 细胞群及其产生的特定细胞因子发生在具有致癌物诱导的口腔癌前病变的小鼠中,以及随着病变发展为口腔癌而发生的变化。这些研究发现,在患有口腔癌前病变的小鼠脾脏和淋巴结中,向 Th1 和 Th17-type 表型倾斜,随着病变发展为癌症,向调节性 t 细胞转移。由于 Th17 细胞在从癌前病变向癌症发展中的作用尚不清楚, 研究确定了用 TGF-β 1 型受体抑制剂加 IL-23 治疗患有口腔癌前病变的小鼠的免疫学和临床效果,以此作为维持 Th17 表型的方法。这些研究表明,这种治疗方法不仅维持了 Th17 表型,还增加了远端脾细胞和区域淋巴结细胞产生的其他刺激/炎症介质,并减缓了癌前病变向癌症的发展。

premalignant lesion

肿瘤 基础研究 临床研究术语
概述  :  

癌前病变,就是癌症出现前的一种疾病形态,常见的有萎缩性胃炎、胃溃疡、胃肠息肉、肝硬化等等。虽然癌前病变还不是癌症,但如果不被重视的话,也有很大的几率发展成癌症。如萎缩性胃炎就有可能发展为胃癌,宫颈糜烂也有可能发展成宫颈癌,Barrett食管可发展成食管癌等等。癌症的发生、发展是由量变到质变、长期演变的过程,大致为正常组织、癌前病变(轻度非典型增生-高度非典型增生/原位癌)、浸润性肿瘤(即癌症)。其中癌前病变及非典型增生即可向正常组织恢复,也可以向癌症恶化,细胞变异程度越低,向正常组织转归的比

Premalignant   /,pri:mə'liɡnənt/

       adj. 恶化前的;癌变前的

       Yet is the premalignant lesion the readily recognized intestinal metaplasia or the more difficult to detect dysplasia? 然而癌前病变是已经公认的肠化生还是更难于探及的不典型增生?

 

Lesion   英 /'liːʒ(ə)n/   美 /'liːʒ(ə)n/

       n. 损害;身体上的伤害;机能障碍

       Therefore, the investigators used it to create a "virtual lesion, " or "block" the influence of the healthy hemisphere and depress inhibition on the affected side of the brain. 因此,研究人员用它建立一种“虚拟损伤”或“阻断”健康的大脑半球的影响,并且消弱受影响一侧大脑所受的抑制。

请扫描右侧二维码,免费查看词汇专业知识背景