释 义 adj. 恶化前的；癌变前的
例 句 Yet is the premalignant lesion the readily recognized intestinal metaplasia or the more difficult to detect dysplasia? 然而癌前病变是已经公认的肠化生还是更难于探及的不典型增生？
Lesion 英 /'liːʒ(ə)n/ 美 /'liːʒ(ə)n/
释 义 n. 损害；身体上的伤害；机能障碍
例 句 Therefore, the investigators used it to create a "virtual lesion, " or "block" the influence of the healthy hemisphere and depress inhibition on the affected side of the brain. 因此，研究人员用它建立一种“虚拟损伤”或“阻断”健康的大脑半球的影响，并且消弱受影响一侧大脑所受的抑制。
作者： Kostyantyn Krysan
Epithelial cells in the field of lung injury can give rise to distinct premalignant lesions that may bear unique genetic aberrations. A subset of these lesions may escape immune surveillance and progress to invasive cancer, however the mutational landscape that may predict progression has not been determined. Knowledge of premalignant lesion composition and the associated microenvironment are critical for understanding tumorigenesis and the development of effective preventive and interception strategies. To identify somatic mutations and the extent of immune cell infiltration in adenomatous premalignancy and associated lung adenocarcinomas, we sequenced exomes from 41 lung cancer resection specimens including 89 premalignant atypical adenomatous hyperplasia lesions, 15 adenocarcinomas in situ, and 55 invasive adenocarcinomas and their adjacent normal lung tissues. We defined non-synonymous somatic mutations occurring in both premalignancy and the associated tumor as progression-associated mutations whose predicted neoantigens were highly correlated with infiltration of CD8+ and CD4+ T cells as well as upregulation of PD-L1 in premalignant lesions, suggesting the presence of an adaptive immune response to these neoantigens. Each patient had a unique repertoire of somatic mutations and associated neoantigens. Collectively, these results provide evidence for mutational heterogeneity, pathway dysregulation, and immune recognition in pulmonary premalignancy.