微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > thrombospondin-2
thrombospondin-2

肿瘤

关键词肿瘤 临床研究术语 基础研究

词汇介绍

拓展阅读

解析

Thrombospondin   英 /θrɒmbɒs'pɒndɪn/   美 /θrɒmbɒs'pɒndɪn/ 

       n. 血小板反应蛋白

       Objective To study the role of the balance between thrombospondin-1 (TSP-1) and vascular endothelial growth factor (VEGF) in the neovascularization of hepatocellular carcinoma (HCC). 目的研究血小板反应蛋白1(TSP-1)和血管内皮生长因子(VEGF)的平衡在肝细胞癌(HCC)新生血管生成中的作用。

概述

血小板反应蛋白家族,全称THBSs,包含五种蛋白,THBS1-5,在多处组织重建中发挥作用,如血管生成和肿瘤形成。根据其分子结构不同,分为两类:一型重复序列(全称TSRs)表现在THBS1和THBS2,但在THBS3、THBS4、THBS5中则不存在。THBS1和THBS2中的TSRs和其他一些蛋白共同参与调节血管生成。1990年,Noel Bouck实验室验证了THBS1作为第一种被发现的天然血管生成抑制剂。THBS1抑制血管生成的过程有多重机制参与,THBS1和THBS2中的TSRs与内

A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer复制标题

基于血液的多标记物检测支持早期胰腺癌的鉴别诊断疾病

发表时间:2019-02-12

影响因子:8.1

作者: Andreas W. Berger

期刊:Theranostics

Obviously, proteins released from precursor lesions during tumor progression such as pancreatic intraepithelial neoplasias (PanIN) might serve as innovative and effective diagnostic biomarkers. Thrombospondin-2 is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. THBS2 probably inhibits angiogenesis and depletion of the THBS2 gene in a mouse model increases the susceptibility to cancer. THBS2 is secreted or released from human precursor PanIN organoids and may hence serve as a biomarker for early PDAC. Preclinical data were recently validated in a large cohort with PDAC patients at various disease stages compared to healthy controls and patients with cystic tumors or chronic pancreatitis. Normal pancreatic cells express the THBS2 antigen but under physiological conditions the plasma concentration is low. In contrary, it is highly expressed by PDAC tumor cells and the plasma of PDAC patients shows elevated THBS2 levels. The concentration of THBS2 in plasma is reported to allow the discrimination between resectable PDAC stage I cancer and advanced stage III/IV. However, the mechanism of THBS2 release into the blood stream remains elusive.

译文

显然,在肿瘤进展期间从前体病变释放的蛋白质如胰腺上皮内瘤形成(PanIN)可以作为创新和有效的诊断生物标志物。血小板反应蛋白-2是二硫键连接的同源三聚体糖蛋白,其介导细胞与细胞和细胞与基质的相互作用。 THBS2可能抑制血管生成,并且小鼠模型中THBS2基因的消耗增加了对癌症的易感性。 THBS2从人前体PanIN类器官分泌或释放,因此可用作早期PDAC的生物标志物。与健康对照和患有囊性肿瘤或慢性胰腺炎的患者相比,最近在与不同疾病阶段的PDAC患者的大型队列中验证了临床前数据。正常胰腺细胞表达THBS2抗原,但在生理条件下血浆浓度低。相反,它由PDAC肿瘤细胞高度表达,并且PDAC患者的血浆显示出升高的THBS2水平。据报道,血浆中THBS2的浓度允许区分可切除的PDAC I期癌症和晚期III / IV期。然而,THBS2释放到血流中的机制仍然是难以捉摸的。