Thrombospondin 英 /θrɒmbɒs'pɒndɪn/ 美 /θrɒmbɒs'pɒndɪn/
释 义 n. 血小板反应蛋白
例 句 Objective To study the role of the balance between thrombospondin-1 (TSP-1) and vascular endothelial growth factor (VEGF) in the neovascularization of hepatocellular carcinoma (HCC). 目的研究血小板反应蛋白1（TSP-1）和血管内皮生长因子（VEGF）的平衡在肝细胞癌（HCC）新生血管生成中的作用。
作者： Andreas W. Berger
Obviously, proteins released from precursor lesions during tumor progression such as pancreatic intraepithelial neoplasias (PanIN) might serve as innovative and effective diagnostic biomarkers. Thrombospondin-2 is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. THBS2 probably inhibits angiogenesis and depletion of the THBS2 gene in a mouse model increases the susceptibility to cancer. THBS2 is secreted or released from human precursor PanIN organoids and may hence serve as a biomarker for early PDAC. Preclinical data were recently validated in a large cohort with PDAC patients at various disease stages compared to healthy controls and patients with cystic tumors or chronic pancreatitis. Normal pancreatic cells express the THBS2 antigen but under physiological conditions the plasma concentration is low. In contrary, it is highly expressed by PDAC tumor cells and the plasma of PDAC patients shows elevated THBS2 levels. The concentration of THBS2 in plasma is reported to allow the discrimination between resectable PDAC stage I cancer and advanced stage III/IV. However, the mechanism of THBS2 release into the blood stream remains elusive.