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首页 > 医学词汇大全 > acute myeloid leukemia
acute myeloid leukemia

肿瘤

关键词肿瘤 疾病 血液肿瘤

词汇介绍

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解析

Acute   英 /ə'kjuːt/   美 /ə'kjut/

       adj. 严重的,[医] 急性的;敏锐的;激烈的;尖声的; 比较级 acuter最高级 acutest

同根词   acutely adv. 尖锐地;剧烈地;acuteness n. 剧烈;敏锐;锐利

       They think his illness is acute rather than chronic. 他们认为他的病是急性的,不是慢性的。

 

Myeloid   英 /'maɪəlɒɪd/

       adj. 骨髓的;骨髓状的;由骨髓而来的;脊髓的

同根词   myelofibrosis n. [内科] 骨髓纤维化,骨髓纤维变性;myelography n. 脊髓照相术;[特医] 脊髓造影术;[特医] 脊髓X射线摄影术

       Joanne, a fashion designer, was diagnosed with acute myeloid leukaemia (AML) three years ago. 乔安娜是一位时尚设计师,三年前被诊断出急性骨髓白血病(AML)。

 

Leukemia   英 /lu:'ki:mɪə/   美 /lu'kimɪə/

       n. [内科][肿瘤] 白血病

同根词   leukocytosis n. 白血球增多;[内科] 白细胞增多

       Children are children, whether they have leukemia or not. 孩子就是孩子,不管他们是否有白血病。

概述

急性骨髓性白血病(AML)是由骨髓性白细胞异常增殖引起的血液肿瘤,特点是骨髓内异常细胞快速增殖影响正常血细胞的产生。它一种进展迅速、危及生命的血液肿瘤,可以影响所有年龄段的人群。急性骨髓性白血病是成年人最常见的急性白血病,其发病率随着人的年龄而增加。AML是一类极其凶险的白血病,患者的癌细胞在骨髓中迅速增殖,并妨碍正常血液细胞的产生,导致出现出血和感染症状,甚至危及生命。 现状现阶段,AML的治疗以化疗及造血干细胞移植为主。虽然少数患者被治愈,但对于绝大多数患者来说,这仍是一种绝症

Prediction of acute myeloid leukaemia risk in healthy individuals复制标题

健康人急性髓系白血病风险的预测

发表时间:2018-07-09

影响因子:43.1

作者: Sagi Abelson

期刊:Nature

The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure. The onset of such de novo AML cases is typically preceded by the accumulation of somatic mutations in preleukaemic haematopoietic stem and progenitor cells (HSPCs) that undergo clonal expansion. However, recurrent AML mutations also accumulate in HSPCs during ageing of healthy individuals who do not develop AML, a phenomenon referred to as age-related clonal haematopoiesis (ARCH). Here we use deep sequencing to analyse genes that are recurrently mutated in AML to distinguish between individuals who have a high risk of developing AML and those with benign ARCH. We analysed peripheral blood cells from 95 individuals that were obtained on average 6.3 years before AML diagnosis (pre-AML group), together with 414 unselected age- and gendermatched individuals (control group).

译文

急性髓性白血病(AML)的发病率随着年龄的增长而增加,并且在65岁以后确诊时死亡率超过90%。大多数病例在没有任何可检测的早期症状的情况下出现,并且患者通常出现骨髓衰竭的急性并发症。这种从头AML病例的发作通常先于在经历克隆扩增的青春期前造血干细胞和祖细胞(HSPC)中的体细胞突变的积累。然而,在不发生AML的健康个体的衰老过程中,复发性AML突变也在HSPC中积累,这种现象被称为与年龄相关的克隆造血(ARCH)。在这里,我们使用深度测序来分析在AML中反复发生突变的基因,以区分具有高发生AML风险的个体和具有良性ARCH的个体。我们分析了来自95名个体的外周血细胞,这些个体在AML诊断前平均获得6.3年(AML前组),以及414名未选择的年龄和性别匹配的个体(对照组)。